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Tipranavir

🥰Excellent
Catalog No. T4578Cas No. 174484-41-4
Alias PNU-140690

Tipranavir is a protease inhibitor that inhibits HIV-1 resistant to more than 1 protease inhibitor .Tipranavir effectively inhibits HIV-1 protease enzyme activity and dimerisation and has potent activity against multiple protease inhibitor (PI) HIV-1 isolates (IC50 of 66-410 nM). Tipranavir inhibits SARS-CoV-2 3CLpro activity.

Tipranavir

Tipranavir

🥰Excellent
Purity: 99.66%
Catalog No. T4578Alias PNU-140690Cas No. 174484-41-4
Tipranavir is a protease inhibitor that inhibits HIV-1 resistant to more than 1 protease inhibitor .Tipranavir effectively inhibits HIV-1 protease enzyme activity and dimerisation and has potent activity against multiple protease inhibitor (PI) HIV-1 isolates (IC50 of 66-410 nM). Tipranavir inhibits SARS-CoV-2 3CLpro activity.
Pack SizePriceAvailabilityQuantity
1 mg$125In Stock
5 mg$397In Stock
10 mg$597In Stock
25 mg$935In Stock
50 mg$1,260In Stock
100 mg$1,690In Stock
1 mL x 10 mM (in DMSO)$527In Stock
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Purity:99.66%
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Product Introduction

Bioactivity
Description
Tipranavir is a protease inhibitor that inhibits HIV-1 resistant to more than 1 protease inhibitor .Tipranavir effectively inhibits HIV-1 protease enzyme activity and dimerisation and has potent activity against multiple protease inhibitor (PI) HIV-1 isolates (IC50 of 66-410 nM). Tipranavir inhibits SARS-CoV-2 3CLpro activity.
Targets&IC50
HIV-1 (isolates):66-410 nM, HIV-1 (isolates):8 pM(Ki )
In vitro
Tipranavir (PNU-140690) inhibits HIV-1 protease activity, blocks protease subunit dimerization, and exhibits potent efficacy against a broad range of wild-type and multi-PI-resistant HIV-1 variants.[1]
In vivo
Tipranavir (5 mg/kg ; mouse model): CLtot was 0.17 ± 0.10 L/h/kg, Vss was 0.51 ± 0.14 L/kg, and t1/2 was 5.4 ±0. 3h.[4]
Tipranavir (10 mg/kg ; oral ; rats): got the result of F was 30% compared to 5 mg/kg tipranavir dosing.[4]
AliasPNU-140690
Chemical Properties
Molecular Weight602.66
FormulaC31H33F3N2O5S
Cas No.174484-41-4
SmilesCCC[C@@]1(CCc2ccccc2)CC(O)=C([C@H](CC)c2cccc(NS(=O)(=O)c3ccc(cn3)C(F)(F)F)c2)C(=O)O1
Relative Density.1.313 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
Ethanol: 45.0 mg/mL (74.7 mM)
DMSO: 180.0 mg/mL (298.7 mM ), Sonication is recommended.
Solution Preparation Table
Ethanol/DMSO
1mg5mg10mg50mg
1 mM1.6593 mL8.2966 mL16.5931 mL82.9655 mL
5 mM0.3319 mL1.6593 mL3.3186 mL16.5931 mL
10 mM0.1659 mL0.8297 mL1.6593 mL8.2966 mL
20 mM0.0830 mL0.4148 mL0.8297 mL4.1483 mL
50 mM0.0332 mL0.1659 mL0.3319 mL1.6593 mL
DMSO
1mg5mg10mg50mg
100 mM0.0166 mL0.0830 mL0.1659 mL0.8297 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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