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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $125 | In Stock | |
5 mg | $397 | In Stock | |
10 mg | $597 | In Stock | |
25 mg | $935 | In Stock | |
50 mg | $1,260 | In Stock | |
100 mg | $1,690 | In Stock | |
1 mL x 10 mM (in DMSO) | $527 | In Stock |
Description | Tipranavir is a protease inhibitor that inhibits HIV-1 resistant to more than 1 protease inhibitor .Tipranavir effectively inhibits HIV-1 protease enzyme activity and dimerisation and has potent activity against multiple protease inhibitor (PI) HIV-1 isolates (IC50 of 66-410 nM). Tipranavir inhibits SARS-CoV-2 3CLpro activity. |
Targets&IC50 | HIV-1 (isolates):66-410 nM, HIV-1 (isolates):8 pM(Ki ) |
In vitro | Tipranavir (PNU-140690) inhibits HIV-1 protease activity, blocks protease subunit dimerization, and exhibits potent efficacy against a broad range of wild-type and multi-PI-resistant HIV-1 variants.[1] |
In vivo | Tipranavir (5 mg/kg ; mouse model): CLtot was 0.17 ± 0.10 L/h/kg, Vss was 0.51 ± 0.14 L/kg, and t1/2 was 5.4 ±0. 3h.[4] Tipranavir (10 mg/kg ; oral ; rats): got the result of F was 30% compared to 5 mg/kg tipranavir dosing.[4] |
Alias | PNU-140690 |
Molecular Weight | 602.66 |
Formula | C31H33F3N2O5S |
Cas No. | 174484-41-4 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
Solubility Information | Ethanol: 45.0 mg/mL (74.7 mM) DMSO: 180.0 mg/mL (298.7 mM ), Sonication is recommended. | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
DMSO
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