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Tipranavir
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Purity:99.66%
Tipranavir
Catalog No. T4578Cas No. 174484-41-4
Tipranavir is a protease inhibitor that inhibits HIV-1 resistant to more than 1 protease inhibitor .Tipranavir effectively inhibits HIV-1 protease enzyme activity and dimerisation and has potent activity against multiple protease inhibitor (PI) HIV-1 isolates (IC50 of 66-410 nM). Tipranavir inhibits SARS-CoV-2 3CLpro activity.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $125 | In Stock | |
| 5 mg | $397 | In Stock | |
| 10 mg | $597 | In Stock | |
| 25 mg | $935 | In Stock | |
| 50 mg | $1,260 | In Stock | |
| 100 mg | $1,690 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $527 | In Stock |
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CitedProduct Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Tipranavir is a protease inhibitor that inhibits HIV-1 resistant to more than 1 protease inhibitor .Tipranavir effectively inhibits HIV-1 protease enzyme activity and dimerisation and has potent activity against multiple protease inhibitor (PI) HIV-1 isolates (IC50 of 66-410 nM). Tipranavir inhibits SARS-CoV-2 3CLpro activity. |
| Targets&IC50 | HIV-1 (isolates):66-410 nM, HIV-1 (isolates):8 pM(Ki ) |
| In vitro | Tipranavir (PNU-140690) inhibits HIV-1 protease activity, blocks protease subunit dimerization, and exhibits potent efficacy against a broad range of wild-type and multi-PI-resistant HIV-1 variants.[1] |
| In vivo | Tipranavir (5 mg/kg ; mouse model): CLtot was 0.17 ± 0.10 L/h/kg, Vss was 0.51 ± 0.14 L/kg, and t1/2 was 5.4 ±0. 3h.[4] Tipranavir (10 mg/kg ; oral ; rats): got the result of F was 30% compared to 5 mg/kg tipranavir dosing.[4] |
| Alias | PNU-140690 |
| Molecular Weight | 602.66 |
| Formula | C31H33F3N2O5S |
| Cas No. | 174484-41-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | Ethanol: 45.0 mg/mL (74.7 mM) DMSO: 180.0 mg/mL (298.7 mM ), Sonication is recommended. | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
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