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TP003

Catalog No. T23466Cas No. 628690-75-5

TP003 is a novel non-selective GABAA receptor benzodiazepine site agonist with affinity for α1β2gam2, α2β3gam2, α3β3gam2, α5β2gam2, EC50 of 20.3, 10.6, 3.24, 5.64 nM, respectively. TP003 has antianxiety and partial anticonvulsant activity via the α2GABAA receptor.

TP003

TP003

Purity: 98.00%
Catalog No. T23466Cas No. 628690-75-5
TP003 is a novel non-selective GABAA receptor benzodiazepine site agonist with affinity for α1β2gam2, α2β3gam2, α3β3gam2, α5β2gam2, EC50 of 20.3, 10.6, 3.24, 5.64 nM, respectively. TP003 has antianxiety and partial anticonvulsant activity via the α2GABAA receptor.
Pack SizePriceAvailabilityQuantity
1 mg$39In Stock
5 mg$89In Stock
10 mg$147In Stock
25 mg$295In Stock
50 mg$442In Stock
100 mg$638In Stock
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Purity:98.00%
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Product Introduction

Bioactivity
Description
TP003 is a novel non-selective GABAA receptor benzodiazepine site agonist with affinity for α1β2gam2, α2β3gam2, α3β3gam2, α5β2gam2, EC50 of 20.3, 10.6, 3.24, 5.64 nM, respectively. TP003 has antianxiety and partial anticonvulsant activity via the α2GABAA receptor.
In vivo
In rats, TP003, a highly a3-selective agonist in vitro, displays an anxiolytic-like action in the elevated plus maze and in the stress-induced hyperthermia test, and in non-human primate behavioral models of anxiety.[1]
Chemical Properties
Molecular Weight407.39
FormulaC23H16F3N3O
Cas No.628690-75-5
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
Ethanol: 18.4 mg/mL (45.0 mM)
DMSO: 36.6 mg/mL (90.0 mM)
Solution Preparation Table
Ethanol/DMSO
1mg5mg10mg50mg
1 mM2.4547 mL12.2733 mL24.5465 mL122.7325 mL
5 mM0.4909 mL2.4547 mL4.9093 mL24.5465 mL
10 mM0.2455 mL1.2273 mL2.4547 mL12.2733 mL
20 mM0.1227 mL0.6137 mL1.2273 mL6.1366 mL
DMSO
1mg5mg10mg50mg
50 mM0.0491 mL0.2455 mL0.4909 mL2.4547 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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