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TP003

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Purity:98%

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COA HNMR HPLC

TP003

Catalog No. T23466Cas No. 628690-75-5

TP003 is a novel non-selective GABAA receptor benzodiazepine site agonist with affinity for α1β2gam2, α2β3gam2, α3β3gam2, α5β2gam2, EC50 of 20.3, 10.6, 3.24, 5.64 nM, respectively. TP003 has antianxiety and partial anticonvulsant activity via the α2GABAA receptor.

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Pack Size	Price	Availability
1 mg	$51	In Stock
5 mg	$122	In Stock
10 mg	$179	In Stock
25 mg	$295	In Stock
50 mg	$448	In Stock
100 mg	$659	In Stock

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Product Introduction

Bioactivity

Description	TP003 is a novel non-selective GABAA receptor benzodiazepine site agonist with affinity for α1β2gam2, α2β3gam2, α3β3gam2, α5β2gam2, EC50 of 20.3, 10.6, 3.24, 5.64 nM, respectively. TP003 has antianxiety and partial anticonvulsant activity via the α2GABAA receptor.
In vivo	In rats, TP003, a highly a3-selective agonist in vitro, displays an anxiolytic-like action in the elevated plus maze and in the stress-induced hyperthermia test， and in non-human primate behavioral models of anxiety.[1]

Chemical Properties

Molecular Weight	407.39
Formula	C23H16F3N3O
Cas No.	628690-75-5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 18.4 mg/mL (45.0 mM)

DMSO: 36.6 mg/mL (90.0 mM)

Solution Preparation Table

DMSO/Ethanol

	1mg	5mg	10mg	50mg
1 mM	2.4547 mL	12.2733 mL	24.5465 mL	122.7325 mL
5 mM	0.4909 mL	2.4547 mL	4.9093 mL	24.5465 mL
10 mM	0.2455 mL	1.2273 mL	2.4547 mL	12.2733 mL
20 mM	0.1227 mL	0.6137 mL	1.2273 mL	6.1366 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0491 mL	0.2455 mL	0.4909 mL	2.4547 mL
100 mM	0.0245 mL	0.1227 mL	0.2455 mL	1.2273 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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