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TZ9
🥰Excellent
Catalog No. T17187Cas No. 1002789-86-7
TZ9 is a selective and potent Rad6 inhibitor with anticancer and anti-tumor activity.TZ9 inhibits Rad6B-induced ubiquitination of histone H2A.TZ9 induces cell cycle arrest and apoptosis.
TZ9
🥰Excellent
Purity: 99.69%
Catalog No. T17187Cas No. 1002789-86-7
TZ9 is a selective and potent Rad6 inhibitor with anticancer and anti-tumor activity.TZ9 inhibits Rad6B-induced ubiquitination of histone H2A.TZ9 induces cell cycle arrest and apoptosis.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $46 | In Stock | |
| 5 mg | $72 | In Stock | |
| 10 mg | $129 | In Stock | |
| 25 mg | $267 | In Stock | |
| 50 mg | Inquiry | In Stock |
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Purity:99.69%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | TZ9 is a selective and potent Rad6 inhibitor with anticancer and anti-tumor activity.TZ9 inhibits Rad6B-induced ubiquitination of histone H2A.TZ9 induces cell cycle arrest and apoptosis. |
| In vitro | In MDA-MB-231 cells, TZ9 (Rad6B SMI #9) inhibits proliferation and migration when administered at concentrations ranging from 0.5 to 100 µM for 72 hours[1]. Cell-cycle progression delay is observed in MDA-MB-231 cells treated with TZ9 at concentrations ranging from 0.1 to 5 µM over a period of 24 to 72 hours[1]. Apoptosis induction is noted in MDA-MB-231 cells exposed to TZ9 at a concentration of 5 µM for 8 to 48 hours[1]. In MDA-MB-231 cells, TZ9 exhibits inhibitory effects on H2A ubiquitination and downregulates levels of PCNA and β-catenin protein when applied at concentrations of 0.5, 1, 2.5, and 5 µM for 24 hours[1]. |
| Molecular Weight | 366.33 |
| Formula | C17H14N6O4 |
| Cas No. | 1002789-86-7 |
| Smiles | Nc1nc(COC(=O)c2ccc(cc2)[N+]([O-])=O)nc(Nc2ccccc2)n1 |
| Relative Density. | 1.477 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 40 mg/mL (109.19 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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