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UK-240455
🥰Excellent
Catalog No. T13248Cas No. 178908-09-3
UK-240455 is a potent and selective N-methyl-D-aspartic acid (NMDA) glycine receptor antagonist with neuroprotective effects and improvements in motor function in Parkinson's disease models, making it a potential candidate for Parkinson's disease treatment.
UK-240455
🥰Excellent
Purity: 99.83%
Catalog No. T13248Cas No. 178908-09-3
UK-240455 is a potent and selective N-methyl-D-aspartic acid (NMDA) glycine receptor antagonist with neuroprotective effects and improvements in motor function in Parkinson's disease models, making it a potential candidate for Parkinson's disease treatment.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | 332 € | In Stock | |
| 5 mg | 786 € | In Stock | |
| 10 mg | 1.073 € | In Stock | |
| 25 mg | 1.510 € | In Stock | |
| 50 mg | 1.881 € | In Stock | |
| 100 mg | 2.375 € | In Stock | |
| 500 mg | 4.655 € | In Stock | |
| 1 mL x 10 mM (in DMSO) | 680 € | In Stock |
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Purity:99.83%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | UK-240455 is a potent and selective N-methyl-D-aspartic acid (NMDA) glycine receptor antagonist with neuroprotective effects and improvements in motor function in Parkinson's disease models, making it a potential candidate for Parkinson's disease treatment. |
| In vivo | After i.v. administration of UK-240455 to male rats, UK-240455 exhibits a clearance of 12 mL/min/kg and a volume of distribution of 0.4 L/kg. The plasma concentration of UK-240455 shows a decrease with an apparent half-life of 0.4 h. The analysis of urine (0 to 24 h) reveals that 57% of the administered dose is excreted unchanged. Thus, the urine clearance rate of UK-240455 in rats amounts to 7 mL/min/kg. Upon oral administration to male rats, the apparent elimination half-life of UK-240455 from plasma was observed to be 1.6 hours.[1] |
| Molecular Weight | 368.19 |
| Formula | C11H11Cl2N3O5S |
| Cas No. | 178908-09-3 |
| Smiles | N(CCO)(S(C)(=O)=O)C1=C2C(=CC(Cl)=C1Cl)NC(=O)C(=O)N2 |
| Relative Density. | 1.686 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 12 mg/mL (32.59 mM)  | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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