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Vidupiprant
Catalog No. T17232Cas No. 1169483-24-2
Alias AMG 853
Vidupiprant (AMG 853) is an effective dual antagonist of CRTH2 and prostanoid D receptor with IC50s of 8 nM and 35 nM in human plasma. Vidupiprant can be used in studies about the treatment of asthma.
Vidupiprant
Catalog No. T17232Alias AMG 853Cas No. 1169483-24-2
Vidupiprant (AMG 853) is an effective dual antagonist of CRTH2 and prostanoid D receptor with IC50s of 8 nM and 35 nM in human plasma. Vidupiprant can be used in studies about the treatment of asthma.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $61 | In Stock | |
| 5 mg | $147 | In Stock | |
| 10 mg | $229 | In Stock | |
| 25 mg | $417 | In Stock | |
| 50 mg | $622 | In Stock | |
| 100 mg | $885 | In Stock | |
| 500 mg | $1,780 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $198 | In Stock |
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Purity:97.16%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Vidupiprant (AMG 853) is an effective dual antagonist of CRTH2 and prostanoid D receptor with IC50s of 8 nM and 35 nM in human plasma. Vidupiprant can be used in studies about the treatment of asthma. |
| In vitro | Vidupiprant inhibits prostaglandin D2-induced cAMP response in platelets in 80% human whole blood with a Kb of 4.7 nM. Vidupiprant inhibits the prostaglandin D2 -induced down-modulation of CRTH2 on CD16 negative granulocytes in human whole blood with a Kb of 0.2 nM. Vidupiprant demonstrates antagonist activity in an aequorin assay using CRTH2-transfected HEK 293 cells and an eosinophil shape change assay[1]. |
| In vivo | In a guinea pig model of PGD2-induced airway constriction, airway resistance is measured in response to PGD2 challenge. Vidupiprant has a Kb of 5 nM[1]. |
| Alias | AMG 853 |
| Molecular Weight | 609.49 |
| Formula | C28H27Cl2FN2O6S |
| Cas No. | 1169483-24-2 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 95 mg/mL (155.87 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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