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YAP/TAZ inhibitor-2
Catalog No. T60218Cas No. 2762617-31-0
YAP/TAZ inhibitor-2 is a potent, orally active TEAD-YAP/TAZ inhibitor with an EC50 value of 3 nM, demonstrating anti-proliferative and antitumor activity [1].
YAP/TAZ inhibitor-2
Catalog No. T60218Cas No. 2762617-31-0
YAP/TAZ inhibitor-2 is a potent, orally active TEAD-YAP/TAZ inhibitor with an EC50 value of 3 nM, demonstrating anti-proliferative and antitumor activity [1].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $84 | In Stock | |
| 2 mg | $122 | In Stock | |
| 5 mg | $197 | In Stock | |
| 10 mg | $313 | In Stock | |
| 25 mg | $528 | In Stock | |
| 50 mg | $763 | In Stock | |
| 100 mg | $1,070 | In Stock | |
| 500 mg | $2,130 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $218 | In Stock |
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CitedSelect Batch
Purity:98.84%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | YAP/TAZ inhibitor-2 is a potent, orally active TEAD-YAP/TAZ inhibitor with an EC50 value of 3 nM, demonstrating anti-proliferative and antitumor activity [1]. |
| In vitro | YAP/TAZ inhibitor-2 (compound 5) exhibits antiproliferative activity in NCI-H226 cells, with an IC50 value of 5.33 nM over 24 hours at concentrations ranging from 0 to 20000 nM [1]. |
| In vivo | YAP/TAZ inhibitor-2 (0.5, 2, 5, 50 mg/kg; p.o.; daily for 28 days) exhibits anti-tumor activity without significant body weight loss during the treatment in BALB/c nude mice (NCI-H226 xenograft model) [1]. |
| Molecular Weight | 390.33 |
| Formula | C19H14F4N4O |
| Cas No. | 2762617-31-0 |
Storage & Solubility Information
| Storage | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 90 mg/mL (230.6 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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