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Zegocractin

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Purity:99.59%

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COA HPLC HNMR

Zegocractin

Catalog No. TQ0033Cas No. 1713240-67-5

Zegocractin (CM-4620) is a calcium-release activated calcium-channel (CRAC channel) inhibitor.

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Pack Size	Price	Availability
1 mg	$128	In Stock
5 mg	$272	In Stock
10 mg	$455	In Stock
25 mg	$753	In Stock
50 mg	$1,050	In Stock
100 mg	$1,420	In Stock
1 mL x 10 mM (in DMSO)	$297	In Stock

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Product Introduction

Bioactivity

Description	Zegocractin (CM-4620) is a calcium-release activated calcium-channel (CRAC channel) inhibitor.
In vitro	CM-4620 (compound 1) is more potent on Orai1 than Orai2-type CRAC channels. In human PBMCs, CM-4620 potently inhibits release of multiple cytokines which play important roles in T cells (IC50s, IFN γ: 138 nM, IL-6: 135 nM, IL-4: 879 nM, IL-1β: 240 nM, IL-10: 303 nM, IL-2: 59 nM, TNFα: 225 nM, IL-17 120 nM) [1].
In vivo	Mouse PACs are treated with CRAC inhibitors GSK-7975A or CM-4620 and monitored for their rate of Calcium uptake. Both CRAC inhibitors reduce the rate of store-operated Calcium entry into the ER to 50% of control levels upon treatment with 700 nM of inhibitor. CM-4620 blocks 100% of the reuptake at 10 mM.
Alias	CM-4620, N-(5-(6-Chloro-2,2-difluorobenzo[d][1,3]dioxol-5-yl)pyrazin-2-yl)-2-fluoro-6-methylbenzamide, CM4620

Chemical Properties

Molecular Weight	421.76
Formula	C19H11ClF3N3O3
Cas No.	1713240-67-5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: Insoluble

DMSO: 100 mg/mL (237.10 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3710 mL	11.8551 mL	23.7102 mL	118.5508 mL
5 mM	0.4742 mL	2.3710 mL	4.7420 mL	23.7102 mL
10 mM	0.2371 mL	1.1855 mL	2.3710 mL	11.8551 mL
20 mM	0.1186 mL	0.5928 mL	1.1855 mL	5.9275 mL
50 mM	0.0474 mL	0.2371 mL	0.4742 mL	2.3710 mL
100 mM	0.0237 mL	0.1186 mL	0.2371 mL	1.1855 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

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