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ZINC69391

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Catalog No. T24833Cas No. 303094-67-9
Alias ZINC-69391, ZINC 69391, N'-(4,6-dimethylpyrimidin-2-yl)-N-[2-(trifluoromethyl)phenyl]guanidine, CysHHC10 acetate(1408311-03-4 free base)

ZINC69391 (CysHHC10 acetate(1408311-03-4 free base)) is a selective inhibitor of Rac1 with antiproliferative and antimetastatic effects. ZINC69391 interferes with the interaction of Rac1 with Dock180, reduces Rac1-GTP levels and induces apoptosis.

ZINC69391

ZINC69391

🥰Excellent
Catalog No. T24833Alias ZINC-69391, ZINC 69391, N'-(4,6-dimethylpyrimidin-2-yl)-N-[2-(trifluoromethyl)phenyl]guanidine, CysHHC10 acetate(1408311-03-4 free base)Cas No. 303094-67-9
ZINC69391 (CysHHC10 acetate(1408311-03-4 free base)) is a selective inhibitor of Rac1 with antiproliferative and antimetastatic effects. ZINC69391 interferes with the interaction of Rac1 with Dock180, reduces Rac1-GTP levels and induces apoptosis.
Pack SizePriceAvailabilityQuantity
1 mg$44In Stock
2 mg$64In Stock
5 mg$107In Stock
10 mg$173In Stock
25 mg$313In Stock
50 mg$437In Stock
100 mg$592In Stock
200 mg$783In Stock
1 mL x 10 mM (in DMSO)$119In Stock
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Product Introduction

Bioactivity
Description
ZINC69391 (CysHHC10 acetate(1408311-03-4 free base)) is a selective inhibitor of Rac1 with antiproliferative and antimetastatic effects. ZINC69391 interferes with the interaction of Rac1 with Dock180, reduces Rac1-GTP levels and induces apoptosis.
In vitro
In U-87 MG and LN229 cells, ZINC69391 (0-125 μM) reduces cell proliferation of human glioma cells. ZINC69391 (50-100 μM) triggers cell cycle arrest[1]. ZINC69391 inhibits the growth of U937, HL-60, KG1A, and Jurkat cells (IC50s = 41-54 μM). In HL-60, U937, and KG1A cell lines, ZINC69391 (50 μM) triggers an increase in apoptotic cells. In LN229 cells, ZINC69391 (50 and 100 μM) augments the enzymatic activity of caspase 3 and increases the percentage of cells in the sub-G0/G1 phase in a concentration-dependent manner[3].
In vivo
In specific pathogen-free female BALB/c inbred mice (bearing F3II cells), ZINC69391 (25 mg/kg; i.p) impairs metastatic lung colonization and reduces by about 60% the formation of total metastatic lung colonies[2].
AliasZINC-69391, ZINC 69391, N'-(4,6-dimethylpyrimidin-2-yl)-N-[2-(trifluoromethyl)phenyl]guanidine, CysHHC10 acetate(1408311-03-4 free base)
Chemical Properties
Molecular Weight309.29
FormulaC14H14F3N5
Cas No.303094-67-9
SmilesCc1cc(C)nc(NC(=N)Nc2ccccc2C(F)(F)F)n1
Relative Density.1.35 g/cm3 (Predicted)
Storage & Solubility Information
Storagestore at low temperature,keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 20 mg/mL (64.66 mM), Sonication and heating to 60℃ are recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.2332 mL16.1661 mL32.3321 mL161.6606 mL
5 mM0.6466 mL3.2332 mL6.4664 mL32.3321 mL
10 mM0.3233 mL1.6166 mL3.2332 mL16.1661 mL
20 mM0.1617 mL0.8083 mL1.6166 mL8.0830 mL
50 mM0.0647 mL0.3233 mL0.6466 mL3.2332 mL

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