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ZL0580

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Purity:99.87%

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COA LCMS HNMR

ZL0580

Catalog No. T13974Cas No. 2377151-10-3

ZL0580 induces HIV suppression by inhibiting Tat transactivation and transcription elongation as well as by inducing repressive chromatin structure at the HIV promoter.

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Pack Size	Price	Availability
1 mg	$38	In Stock
2 mg	$54	In Stock
5 mg	$89	In Stock
10 mg	$155	In Stock
25 mg	$288	In Stock
50 mg	$425	In Stock
100 mg	$628	In Stock
1 mL x 10 mM (in DMSO)	$98	In Stock

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Product Introduction

Bioactivity

Description	ZL0580 induces HIV suppression by inhibiting Tat transactivation and transcription elongation as well as by inducing repressive chromatin structure at the HIV promoter.
In vitro	In PBMCs of viremic HIV-infected individuals,ZL0580 (8 μM, 2 days) induces HIV transcriptional suppression with low toxicity[1]. ZL0580 treatment (10 μM) suppresses both PMA-stimulated and basal HIV transcription[1].

Chemical Properties

Molecular Weight	532.53
Formula	C25H23F3N4O4S
Cas No.	2377151-10-3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 250 mg/mL (469.46 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8778 mL	9.3891 mL	18.7783 mL	93.8914 mL
5 mM	0.3756 mL	1.8778 mL	3.7557 mL	18.7783 mL
10 mM	0.1878 mL	0.9389 mL	1.8778 mL	9.3891 mL
20 mM	0.0939 mL	0.4695 mL	0.9389 mL	4.6946 mL
50 mM	0.0376 mL	0.1878 mL	0.3756 mL	1.8778 mL
100 mM	0.0188 mL	0.0939 mL	0.1878 mL	0.9389 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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