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(E/Z)-4-Hydroxytamoxifen

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Purity:99.1%

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COA HNMR HPLC

(E/Z)-4-Hydroxytamoxifen

Catalog No. T6743Cas No. 68392-35-8

(E/Z)-4-Hydroxytamoxifen (Afimoxifene) is the active metabolite of tamoxifen and a selective estrogen receptor (ER) modulator that is widely used in the therapeutic and chemopreventive treatment of breast cancer.

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Pack Size	Price	Availability
5 mg	$47	In Stock
10 mg	$72	In Stock
25 mg	$129	In Stock
50 mg	$213	In Stock
100 mg	$328	In Stock
200 mg	$493	In Stock
500 mg	$789	In Stock
1 mL x 10 mM (in DMSO)	$52	In Stock

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Product Introduction

Bioactivity

Description	(E/Z)-4-Hydroxytamoxifen (Afimoxifene) is the active metabolite of tamoxifen and a selective estrogen receptor (ER) modulator that is widely used in the therapeutic and chemopreventive treatment of breast cancer.
In vitro	4-OHT is a potent activator of ER and has been shown to have a higher affinity for estrogen receptors compared to tamoxifen. It has significant dose and time-dependent direct effects to alter the contractile function of isolated adult rat cardiac myocytes. 4-HT activates on-target modification frequency for intein-Cas9 variants
Cell Research	Cell lines: Adult Rat and Mouse Cardiac MyocytesConcentrations: 0, 0.5, 1, 3, 5, and 10 μMIncubation Time: 15-45 minMethod:For sarcomere length measurements, cells are covered in Tyrode's containing 4OHT, allowed to reach 36 ± 1°C, and then stimulated at 0.2 Hz.
Animal Research	Animal Models: Sprague-Dawley ratsFormulation: dissolved in 200 μl tricaprylinDosages: 21 mg/kg, 54 μmol/kgAdministration: oral administration
Alias	Afimoxifene, 4-Hydroxytamoxifen

Chemical Properties

Molecular Weight	387.51
Formula	C26H29NO2
Cas No.	68392-35-8

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/mL (154.83 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5806 mL	12.9029 mL	25.8058 mL	129.0289 mL
5 mM	0.5161 mL	2.5806 mL	5.1612 mL	25.8058 mL
10 mM	0.2581 mL	1.2903 mL	2.5806 mL	12.9029 mL
20 mM	0.1290 mL	0.6451 mL	1.2903 mL	6.4514 mL
50 mM	0.0516 mL	0.2581 mL	0.5161 mL	2.5806 mL
100 mM	0.0258 mL	0.1290 mL	0.2581 mL	1.2903 mL

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In Vivo Formulation Calculator (Clear solution)

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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