Powder: -20°C for 3 years | In solvent: -80°C for 1 year
δ-Tocotrienol (Delta-Tocotrienol) is a potential angiogenic inhibitor. δ-Tocotrienol is also a nontoxic activator of mir-34a which can inhibit nonsmall cell lung cancer cells (NSC-LC) cell proliferation, induce apoptosis and inhibit invasion, and thus offering a potential starting point for the design of novel anticancer agents.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 59.00 | |
5 mg | In stock | $ 122.00 | |
10 mg | In stock | $ 197.00 | |
25 mg | In stock | $ 397.00 | |
50 mg | In stock | $ 589.00 | |
100 mg | In stock | $ 843.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 133.00 |
Description | δ-Tocotrienol (Delta-Tocotrienol) is a potential angiogenic inhibitor. δ-Tocotrienol is also a nontoxic activator of mir-34a which can inhibit nonsmall cell lung cancer cells (NSC-LC) cell proliferation, induce apoptosis and inhibit invasion, and thus offering a potential starting point for the design of novel anticancer agents. |
In vitro | δ-Tocotrienol induced apoptosis and cell cycle arrest at G0/G1 and M phases in nasopharyngeal carcinoma cells. After CNE1 cells were treated with δ-Tocotrienol, 169 genes were up-regulated and 167 down-regulated. ERK1/2 was shown to play a vital role in cell cycle arrest by gene chips. δ-Tocotrienol induces cell cycle arrest in CNE1 cells via the p16/CDK4/cyclin D1 signaling pathway. CNE1 apoptosis was related to dysregulated expression of Bax-2 and Bcl-2. Furthermore, caspase-3, -8, -9 up-regulation was related to the apoptotic effect of δ-Tocotrienol[1]. |
Source |
Synonyms | Delta-Tocotrienol |
Molecular Weight | 396.61 |
Formula | C27H40O2 |
CAS No. | 25612-59-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (252.14 mM)
You can also refer to dose conversion for different animals. More
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δ-Tocotrienol 25612-59-3 Angiogenesis Apoptosis Cytoskeletal Signaling MAPK PI3K/Akt/mTOR signaling Tyrosine Kinase/Adaptors VEGFR BCL ERK PDK Akt PI3K p53 inhibit δ Tocotrienol Inhibitor δTocotrienol Δ-Tocotrienol Delta-Tocotrienol inhibitor