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3,3'-Diindolylmethane (DIM), a small molecule compound, is a proposed Y preventive agent.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
50 mg | $39 | In Stock | |
100 mg | $53 | In Stock | |
200 mg | $62 | In Stock | |
500 mg | $81 | In Stock | |
1 mL x 10 mM (in DMSO) | $57 | In Stock |
Description | 3,3'-Diindolylmethane (DIM), a small molecule compound, is a proposed Y preventive agent. |
In vitro | 3,3'-Diindolylmethane is a potent radioprotector and mitigator that functions by stimulating an ATM-driven DDR-like response and NF-κB survival signaling. 3,3'-Diindolylmethane can inhibit invasion, angiogenesis, and proliferation and induce apoptosis in tumor cells by modulating signaling pathways involving AKT, NF-κB, and FOXO3. It can also inhibit estrogen-inducible gene expression and cause an endoplasmic reticulum stress response. 3,3'-Diindolylmethane alters estrogen metabolism by shifting metabolism from carcinogenic 16α-hydroxy to inert 2-hydroxy derivatives, and it antagonizes estrogen and androgen receptor activity[1]. |
In vivo | Preliminary studies show 3,3'-Diindolylmethane is most effective against total body irradiation (TBI) when given in multiple once-daily doses. Treatment of 3,3'-Diindolylmethane has radioprotection and mitigation properties in vivo. 3,3'-Diindolylmethane Activates ATM in Normal Tissues. 3,3'-Diindolylmethane can be given to mice (250 mg/kg) by oral gavage, with no acute toxicity and excellent bioavailability[1]. |
Cell Research | The 184A1 and Hs578Bst cells are pretreated with DIM (0.3 μM) or vehicle for 24 h, irradiated by using different doses of 137Cs γ rays, harvested, plated at different densities, incubated for 14 d, and counted for colony formation.(Only for Reference) |
Alias | HB 236, DIM, Arundine |
Molecular Weight | 246.31 |
Formula | C17H14N2 |
Cas No. | 1968-05-4 |
Smiles | C(C1=CNC2=C1C=CC=C2)C1=CNC2=C1C=CC=C2 |
Relative Density. | 1.271 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
Solubility Information | Ethanol: 18 mg/mL (73.08 mM) DMSO: 50 mg/mL (203 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
DMSO
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