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3-Aminopropylphosphonic Acid
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Purity:98.9%
3-Aminopropylphosphonic Acid
Catalog No. T38205Cas No. 13138-33-5
3-aminopropylphosphonic acid (3-APPA) is a phosphonic analog of GABA that acts as a partial agonist of GABAB receptors (IC50 = 1.5 μM in a radioligand binding assay).
With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $40 | In Stock | |
| 10 mg | $56 | In Stock | |
| 25 mg | $90 | In Stock | |
| 50 mg | $129 | In Stock | |
| 100 mg | $197 | In Stock | |
| 500 mg | $496 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $40 | In Stock |
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CitedProduct Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | 3-aminopropylphosphonic acid (3-APPA) is a phosphonic analog of GABA that acts as a partial agonist of GABAB receptors (IC50 = 1.5 μM in a radioligand binding assay). |
| In vitro | 3-aminopropylphosphonic acid (IC50 1.5 microM) and 4-aminobutyl-phosphonic acid (IC50 3.9 μM) were much more potent than anticipated from their relatively weak GABAB antagonist actions [1]. 3-aminopropylphosphonic acid was a potent inhibitor (IC50 6μM) of the binding of [3H]GABA to rat brain membranes under GABAB conditions, i.e. in the presence of 0.1 mM isoguvacine and displaceable by 0.1 mM (+)-baclofen [1]. |
| In vivo | 3-aminopropylphosphonic acid induces relaxation in unstimulated isolated guinea pig ileum longitudinal muscle and reverses GABA- and baclofen-induced inhibition of twitch responses in isolated guinea pig ileum longitudinal muscle. 3-APPA (5 mg/kg) completely inhibits GABA- and baclofen-induced inhibition of vagally stimulated bronchospasms in guinea pigs. It also reverses the antitussive effect of baclofen in cats when administered at a dose of 3 mg/kg. |
| Molecular Weight | 139.09 |
| Formula | C3H10NO3P |
| Cas No. | 13138-33-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMF: 5 mg/mL Ethanol: 30 mg/mL DMSO: < 1 mg/mL (insoluble）  Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/mL |
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