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5-LOX-IN-2
🥰Excellent
Catalog No. T77528Cas No. 179691-97-5
5-LOx-in-2 is a 5-lipoxygenase inhibitor (5-LOX) with an IC50 value of 0.33 μM. 5-lox-in-2 inhibits 5-LOX action IN a dose-dependent manner. 5-LOX-IN-2 can reduce the cell activity of kidney cancer cells and induce apoptosis, and can be used in cancer research.
5-LOX-IN-2
🥰Excellent
Purity: 99.18%
Catalog No. T77528Cas No. 179691-97-5
5-LOx-in-2 is a 5-lipoxygenase inhibitor (5-LOX) with an IC50 value of 0.33 μM. 5-lox-in-2 inhibits 5-LOX action IN a dose-dependent manner. 5-LOX-IN-2 can reduce the cell activity of kidney cancer cells and induce apoptosis, and can be used in cancer research.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $52 | In Stock | |
| 5 mg | $193 | In Stock | |
| 10 mg | $333 | In Stock | |
| 25 mg | $597 | In Stock | |
| 50 mg | $868 | In Stock | |
| 100 mg | $1,180 | In Stock | |
| 500 mg | $2,390 | In Stock |
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Purity:99.18%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | 5-LOx-in-2 is a 5-lipoxygenase inhibitor (5-LOX) with an IC50 value of 0.33 μM. 5-lox-in-2 inhibits 5-LOX action IN a dose-dependent manner. 5-LOX-IN-2 can reduce the cell activity of kidney cancer cells and induce apoptosis, and can be used in cancer research. |
| Targets&IC50 | 5-LOX:0.33 μM |
| In vitro | 5-LOX-IN-2 at a concentration of 0-100 μM, after 4 days of action, reduced the activity of renal cancer cells (RCC4, RCC10, 786.0 cells) and showed higher selectivity for RCC4 and 786.0 cells deficient in the von Hippel-Lindau (VHL) tumor suppressor gene. 5-LOX-IN-2 at a concentration of 0-10 μM, after 24 hours of action, was capable of increasing the expression of LC3B and p62, and inducing apoptosis through the activation of the caspase-3 pathway. concentration and after 24 hours of action, it was able to increase the expression of LC3B and p62, block the autophagic flow in RCC4 cells, and induce apoptosis by activating the caspase-3 pathway. |
| Molecular Weight | 284.31 |
| Formula | C17H16O4 |
| Cas No. | 179691-97-5 |
| Smiles | C(=C/C(OCCC1=CC=CC=C1)=O)\C2=C(O)C=CC(O)=C2 |
| Relative Density. | 1.266 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (175.86 mM)  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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