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6-Mercaptopurine hydrate

Catalog No. T2201 CAS 6112-76-1

Synonyms: 6-Mercaptopurine monohydrate, 6-Mercaptopurine (6-MP) Monohydrate

6-Mercaptopurine hydrate (6-Mercaptopurine monohydrate) is a Nucleoside Metabolic Inhibitor. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia.

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6-Mercaptopurine hydrate Chemical Structure

6-Mercaptopurine hydrate, CAS 6112-76-1

Pack Size	Availability	Price/USD
25 mg	In stock	$ 38.00
50 mg	In stock	$ 46.00
100 mg	In stock	$ 62.00
500 mg	In stock	$ 81.00
1 mL * 10 mM (in DMSO)	In stock	$ 29.00

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Purity: 99.92%

Purity: 99%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

In vitro

Mercaptopurine is widely used to treat malignancies, rheumatic diseases, dermatologic conditions, inflammatory bowel disease, and solid organ transplant rejection. [1] Mercaptopurine inhibits purine nucleotide synthesis and metabolism by inhibiting an enzyme called Phosphoribosyl pyrophosphate amidotransferase (PRPP Amidotransferase). PRPP Amidotransferase is the rate limiting enzyme of purine synthesis. It alters the synthesis and function of RNA and DNA. Mercaptopurine interferes with nucleotide interconversion and glycoprotein synthesis. [2]

Synonyms	6-Mercaptopurine monohydrate, 6-Mercaptopurine (6-MP) Monohydrate
Molecular Weight	170.19
Formula	C5H6N4OS
CAS No.	6112-76-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 100 mg/mL

References and Literature

1. Sahasranaman S, et al. Eur J Clin Pharmacol, 2008, 64(8), 753-767. 2. Weinshilboum RM, et al. Am J Hum Genet, 1980, 32(5), 651-662. 3. Fu Y H, Xu Z X, Jiang N, et al. High-throughput screening of active compounds against human respiratory syncytial virus. Virology. 2019.

Citations

1. Fu Y H, Xu Z X, Jiang N, et al. High-throughput screening of active compounds against human respiratory syncytial virus. Virology. 2019

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Clinical Compound Library Inhibitor Library Drug Repurposing Compound Library Anti-Cancer Active Compound Library Anti-Cancer Drug Library Anti-Cancer Approved Drug Library Bioactive Compounds Library Max Anti-Cancer Compound Library Anti-Viral Compound Library Drug-Fragment Library

Related Products

Related compounds with same targets

LNA-Adenosine CNDAC hydrochloride Fludarabine N6,N6-Dimethyladenosine N6-Methyladenine 3'-Deoxy-3'-fluoroguanosine Decitabine 2’-OMe-Guanosine

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

6-Mercaptopurine hydrate 6112-76-1 Cell Cycle/Checkpoint DNA Damage/DNA Repair Others DNA/RNA Synthesis Nucleoside Antimetabolite/Analog Mercaptopurine 6-Mercaptopurine Monohydrate 6Mercaptopurine hydrate Inhibitor 6-MP 6-Mercaptopurine monohydrate 6-Mercaptopurine 6 Mercaptopurine hydrate 6-Mercaptopurine (6-MP) Monohydrate inhibit 6-Mercaptopurine (6-MP) 6-Mercaptopurine Hydrate inhibitor

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