ACBI1

ACBI1 is a potent PROTAC degrader of BAF ATPase subunits SMARCA2 and SMARCA4, also degrades the polybromo-associated BAF (PBAF) complex member PBRM1, with DC50s of 6 nM, 11 nM and 32 nM for SMARCA2, SMARCA4 and PBRM1 in MV-4-11 cells, respectively. ACBI1 is composed of a bromodomain ligand, a linker, and the E3 ubiquitin ligase VHL. ACBI1 can induce anti-proliferative effects and apoptosis.

Catalog No. T17350Cas No. 2375564-55-7

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Purity:98.15%

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COA HNMR HPLC

ACBI1

Catalog No. T17350Cas No. 2375564-55-7

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Pack Size	Price	Availability
1 mg	$59	In Stock
5 mg	$142	In Stock
10 mg	$229	In Stock
25 mg	$383	In Stock
50 mg	$548	In Stock
100 mg	$738	In Stock
200 mg	$993	In Stock

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Product Introduction

Bioactivity

Description	ACBI1 is a potent PROTAC degrader of BAF ATPase subunits SMARCA2 and SMARCA4, also degrades the polybromo-associated BAF (PBAF) complex member PBRM1, with DC50s of 6 nM, 11 nM and 32 nM for SMARCA2, SMARCA4 and PBRM1 in MV-4-11 cells, respectively. ACBI1 is composed of a bromodomain ligand, a linker, and the E3 ubiquitin ligase VHL. ACBI1 can induce anti-proliferative effects and apoptosis.
Targets&IC50	SMARCA2:6 nM (DC50), SMARCA4:11 nM (DC50), PBRM1:32 nM (DC50)

Chemical Properties

Molecular Weight	936.1
Formula	C₄₉H₅₈FN₉O₇S
Cas No.	2375564-55-7

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 100 mg/mL (106.83 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.0683 mL	5.3413 mL	10.6826 mL	53.4131 mL
5 mM	0.2137 mL	1.0683 mL	2.1365 mL	10.6826 mL
10 mM	0.1068 mL	0.5341 mL	1.0683 mL	5.3413 mL
20 mM	0.0534 mL	0.2671 mL	0.5341 mL	2.6707 mL
50 mM	0.0214 mL	0.1068 mL	0.2137 mL	1.0683 mL
100 mM	0.0107 mL	0.0534 mL	0.1068 mL	0.5341 mL

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