Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AKT inhibitor VIII (AKTi-1/2) is a highly specific Akt1/2 inhibitor (IC50: 58/210 nM). The selectivity for Akt1 is higher about 36-fold than Akt3.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 44.00 | |
2 mg | In stock | $ 61.00 | |
5 mg | In stock | $ 107.00 | |
10 mg | In stock | $ 155.00 | |
25 mg | In stock | $ 278.00 | |
50 mg | In stock | $ 455.00 | |
100 mg | In stock | $ 672.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 129.00 |
Description | AKT inhibitor VIII (AKTi-1/2) is a highly specific Akt1/2 inhibitor (IC50: 58/210 nM). The selectivity for Akt1 is higher about 36-fold than Akt3. |
Targets&IC50 | Akt2:210 nM, Akt1:58 nM |
Kinase Assay | Kinase screen: Briefly, all assays (25.5 μl at 21°C for 30 min) are performed using a Biomek 2000 Laboratory Automation Workstation in a 96-well format. Reactions contains 5–20 mU purified kinase along with substrate peptide or protein and are initiated by the addition of 10 mM MgAcetate and 5, 20, or 50 μM ATP ([γ-33P]-ATP, 800 cpm/pmol). |
Cell Research | The cell growth inhibitory effect of AKTi-1/2 is studied using the 96 h sulforhodamine B assay (SRB). Drug concentrations that inhibited 50% of cell growth (IC50) are calculated for each compound in GraphPad Prism 6.0 using non-linear regression analysis and sigmoidal dose–response (variable slope) equation.(Only for Reference) |
Synonyms | AKTi-1/2 |
Molecular Weight | 551.64 |
Formula | C34H29N7O |
CAS No. | 612847-09-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 11 mg/mL (20 mM), with gentle warming
You can also refer to dose conversion for different animals. More
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AKT inhibitor VIII 612847-09-3 Apoptosis Cytoskeletal Signaling PI3K/Akt/mTOR signaling Akt PKB Inhibitor AKTi-1/2 Protein kinase B inhibit inhibitor