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AKT inhibitor VIII

Catalog No. T3346   CAS 612847-09-3
Synonyms: AKTi-1/2

AKT inhibitor VIII (AKTi-1/2) is a highly specific Akt1/2 inhibitor (IC50: 58/210 nM). The selectivity for Akt1 is higher about 36-fold than Akt3.

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AKT inhibitor VIII Chemical Structure
AKT inhibitor VIII, CAS 612847-09-3
Pack Size Availability Price/USD Quantity
1 mg In stock $ 44.00
2 mg In stock $ 61.00
5 mg In stock $ 107.00
10 mg In stock $ 155.00
25 mg In stock $ 278.00
50 mg In stock $ 455.00
100 mg In stock $ 672.00
1 mL * 10 mM (in DMSO) In stock $ 129.00
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Purity: 98.77%
Purity: 98.65%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description AKT inhibitor VIII (AKTi-1/2) is a highly specific Akt1/2 inhibitor (IC50: 58/210 nM). The selectivity for Akt1 is higher about 36-fold than Akt3.
Targets&IC50 Akt2:210 nM, Akt1:58 nM
Kinase Assay Kinase screen: Briefly, all assays (25.5 μl at 21°C for 30 min) are performed using a Biomek 2000 Laboratory Automation Workstation in a 96-well format. Reactions contains 5–20 mU purified kinase along with substrate peptide or protein and are initiated by the addition of 10 mM MgAcetate and 5, 20, or 50 μM ATP ([γ-33P]-ATP, 800 cpm/pmol).
Cell Research The cell growth inhibitory effect of AKTi-1/2 is studied using the 96 h sulforhodamine B assay (SRB). Drug concentrations that inhibited 50% of cell growth (IC50) are calculated for each compound in GraphPad Prism 6.0 using non-linear regression analysis and sigmoidal dose–response (variable slope) equation.(Only for Reference)
Synonyms AKTi-1/2
Molecular Weight 551.64
Formula C34H29N7O
CAS No. 612847-09-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 11 mg/mL (20 mM), with gentle warming

TargetMolReferences and Literature

1. Lindsley CW, et al. Bioorg Med Chem Lett. 2005, 15(3), 761-764. 2. Logie L, et al. Diabetes. 2007, 56(9), 2218-2227. 3. Hunter RW, et al. J Thromb Haemost. 2008, 6(11), 1923-1932. 4. Puglisi M, et al. Lung Cancer. 2014, 85(2), 141-146.

Related compound libraries

This product is contained In the following compound libraries:
Highly Selective Inhibitor Library Cancer Cell Differentiation Compound Library Reprogramming Compound Library Anti-Cancer Metabolism Compound Library Anti-Liver Cancer Compound Library Oxidation-Reduction Compound Library Kinase Inhibitor Library Anti-Obesity Compound Library Bioactive Compound Library Glycolysis Compound Library

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Keywords

AKT inhibitor VIII 612847-09-3 Apoptosis Cytoskeletal Signaling PI3K/Akt/mTOR signaling Akt PKB Inhibitor AKTi-1/2 Protein kinase B inhibit inhibitor

 

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