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AZ7550

Catalog No. T13564 CAS 1421373-99-0

Synonyms: Epidermal growth factor receptor, inhibit, AZ-7550, Inhibitor, ErbB-1, HER1, AZ7550, Drug Metabolite, AZ 7550, IGF-1R, EGFR

AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).

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AZ7550, CAS 1421373-99-0

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Purity: 98%

Biological Description

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Storage & Solubility Information

Description	AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).
Targets&IC50	MLK1:88 nM , MNK2:228 nM , ALK:420 nM , Brk:843 nM , BLK:977 nM , ErbB4:195 nM , Flt4:1784 nM , IGF1R:1.6 μM , FAK:995 nM , FLT3:302 nM , FES:449 nM , Ins R:1256 nM , Ack1:156 nM , PYK2:2288 nM , TEC:1317 nM , IRR:840 nM
In vitro	AZ7550 (Compound 28) inhibits double mutant (DM) cell line H1975, activating mutant (AM) cell line PC9, and wild type (WT) cell line LoVo (IC50s: 45, 26, and 786 nM). AZ7550 inhibits DM antiproliferative cell line H1975, AM antiproliferative cell line PC9, and WT antiproliferative cell line Calu3 (GI50s: 19, 15, and 537 nM).

Synonyms	Epidermal growth factor receptor, inhibit, AZ-7550, Inhibitor, ErbB-1, HER1, AZ7550, Drug Metabolite, AZ 7550, IGF-1R, EGFR
Molecular Weight	485.58
Formula	C27H31N7O2
CAS No.	1421373-99-0

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature

1. Finlay MR, et al. Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptor. J Med Chem. 2014 Oct 23;57(20):8249-67.

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AIM-100 GNF-7 KRCA-0008 Vemurafenib AZ7550

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.