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AZ7550

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Catalog No. T13564Cas No. 1421373-99-0

AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).

AZ7550

AZ7550

🥰Excellent
Purity: 97.07%
Catalog No. T13564Cas No. 1421373-99-0
AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).
Pack SizePriceAvailabilityQuantity
1 mg126 €In Stock
5 mg286 €In Stock
10 mg424 €In Stock
25 mg701 €In Stock
50 mg937 €In Stock
100 mg1.311 €In Stock
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Purity:97.07%
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Product Introduction

Bioactivity
Description
AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).
Targets&IC50
FLT3:302 nM , FAK:995 nM , FES:449 nM , PYK2:2288 nM , Ack1:156 nM , INSR:1256 nM , BLK:977 nM , ALK:420 nM , Brk:843 nM , MNK2:228 nM , MLK1:88 nM , FLT4:1784 nM , IGF-1R:1.6 μM , ERB4:195 nM , TEC:1317 nM , IRR:840 nM
In vitro
AZ7550 (Compound 28) inhibits double mutant (DM) cell line H1975, activating mutant (AM) cell line PC9, and wild type (WT) cell line LoVo (IC50s: 45, 26, and 786 nM). AZ7550 inhibits DM antiproliferative cell line H1975, AM antiproliferative cell line PC9, and WT antiproliferative cell line Calu3 (GI50s: 19, 15, and 537 nM).
Chemical Properties
Molecular Weight485.58
FormulaC27H31N7O2
Cas No.1421373-99-0
SmilesCN1C=C(C=2C1=CC=CC2)C3=NC(NC4=C(OC)C=C(N(CCNC)C)C(NC(C=C)=O)=C4)=NC=C3
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 1 mg/mL, Sonication is recommended.

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