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AZ7550
AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).
Catalog No. T13564Cas No. 1421373-99-0
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Purity:97.07%
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AZ7550
Catalog No. T13564Cas No. 1421373-99-0
AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $133 | In Stock | |
| 5 mg | $302 | In Stock | |
| 10 mg | $447 | In Stock | |
| 25 mg | $738 | In Stock | |
| 50 mg | $987 | In Stock | |
| 100 mg | $1,380 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM). |
| Targets&IC50 | IRR:840 nM , TEC:1317 nM , FES:449 nM , FLT3:302 nM , FAK:995 nM , PYK2:2288 nM , Ack1:156 nM , INSR:1256 nM , BLK:977 nM , Brk:843 nM , ALK:420 nM , ERB4:195 nM , FLT4:1784 nM , IGF-1R:1.6 μM , MNK2:228 nM , MLK1:88 nM |
| In vitro | AZ7550 (Compound 28) inhibits double mutant (DM) cell line H1975, activating mutant (AM) cell line PC9, and wild type (WT) cell line LoVo (IC50s: 45, 26, and 786 nM). AZ7550 inhibits DM antiproliferative cell line H1975, AM antiproliferative cell line PC9, and WT antiproliferative cell line Calu3 (GI50s: 19, 15, and 537 nM). |
| Molecular Weight | 485.58 |
| Formula | C27H31N7O2 |
| Cas No. | 1421373-99-0 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO: 1 mg/mL, Sonication is recommended.  |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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