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Allethrin

Catalog No. T25049 CAS 584-79-2

Allethrin induces oxidative stress, apoptosis and calcium release. Allethrin, a pyrethroid insecticide is a major mosquito repellent agent.

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Allethrin, CAS 584-79-2

Pack Size	Availability	Price/USD
1 mg	In stock	$ 31.00
5 mg	In stock	$ 63.00
10 mg	In stock	$ 89.00
25 mg	In stock	$ 162.00
50 mg	In stock	$ 229.00
100 mg	In stock	$ 329.00
200 mg	In stock	$ 493.00
500 mg	In stock	$ 739.00
1 mL * 10 mM (in DMSO)	In stock	$ 72.00

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Description	Allethrin induces oxidative stress, apoptosis and calcium release. Allethrin, a pyrethroid insecticide is a major mosquito repellent agent.
In vitro	Allethrin (125 μM) induces BCL-2, caspase-3 activation and release of intracellular calcium[1]. Morphological analyses of LC540 cells treated with Allethrin (125 μM) reveals the presence of apoptotic bodies. The percentage of cells displaying early apoptotic features increased significantly[1].
In vivo	In male wistar rats aged 90 day,s Allethrin (25, 50, 100, and 150 mg/kg; every day for 60 days) increased lipid peroxidation in the caput, cauda, and testes[3]. Significant increase in catalase activity was observed in the cauda obtained from 50, 100, and 150 mg/kg. GPx activity was significantly increased in the caput obtained from 150 mg/kg treated rats. In the cauda, it was found to be increased significantly in the 50 and 100 mg/kg treated groups. In contrast, the activity of GPx activity was significantly decreased in the testes of rats treated with 150 mg/kg. GST activity was found to be increased significantly in a dose dependent manner in the caput and cauda of allethrin treated rats[2].

Molecular Weight	302.41
Formula	C19H26O3
CAS No.	584-79-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/ml (198.41 mM)

References and Literature

1. Golla Madhubabu, et al. Allethrin induces oxidative stress, apoptosis and calcium release in rat testicular carcinoma cells (LC540). Toxicol In Vitro. 2014 Dec;28(8):1386-95. 2. Golla Madhubabu, et al. Allethrin induced toxicity in the male reproductive tract of rats contributes to disruption in the transcription of genes involved in germ cell production. Environ Toxicol. 2014 Nov;29(11):1330-45. 3. Geetika Gupta, et al. Allethrin toxicity on human corneal epithelial cells involves mitochondrial pathway mediated apoptosis. Toxicol In Vitro. 2013 Dec;27(8):2242-8.

Related compound libraries

This product is contained In the following compound libraries：

Mitochondria-Targeted Compound Library Bioactive Compounds Library Max Pyroptosis Compound Library Cuproptosis Compound Library Anti-Cancer Compound Library Bioactive Compound Library PPI Inhibitor Library

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Keywords

Allethrin 584-79-2 Apoptosis Proteases/Proteasome BCL Caspase mosquito calcium release sperm maturation insecticide inhibit repellent epididymis Pyrethroid stress Inhibitor testis oxidative inhibitor

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