Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Allitinib (AST-1306) (AST-1306) has anti-cancer activity,and it is an irreversible EGFR and ErbB2 inhibitor with IC50s of 0.5 and 3 nM, respectively. [1]
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 79.00 | |
5 mg | In stock | $ 193.00 | |
10 mg | In stock | $ 288.00 | |
25 mg | In stock | $ 487.00 | |
50 mg | In stock | $ 693.00 | |
100 mg | In stock | $ 963.00 | |
500 mg | In stock | $ 1,930.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 219.00 |
Description | Allitinib (AST-1306) (AST-1306) has anti-cancer activity,and it is an irreversible EGFR and ErbB2 inhibitor with IC50s of 0.5 and 3 nM, respectively. [1] |
Targets&IC50 | EGFR:0.5 nM, EGFR (L858R/T790M):12 nM, ERB4:0.8 nM, ErbB2:3 nM |
In vitro | AST1306 (AST-1306; 0.19-6.25 μM; 72 hours) inhibit the growth of HIH3T3-EGFR T790M/L858R cells[1]. AST1306 (0.001-1.0 μM; 4 hours) is more than 3000-fold selective for ErbB family kinases over other kinase families[1]. AST1306 inhibits the activation of tyrosine kinases and downstream signaling pathways in A549 cells, Calu-3 cells and SK-OV-3 cells,and dose-dependently and markedly inhibits EGF-induced EGFR phosphorylation in A549 cells[1]. |
In vivo | AST1306 (AST-1306; oral; 25-100 mg/kg) significantly inhibited tumor growth in SK-OV-3 and Calu-3 xenograft models[1]. |
Synonyms | AST-1306, ALS 1306 |
Molecular Weight | 448.88 |
Formula | C24H18ClFN4O2 |
CAS No. | 897383-62-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 20 mg/mL (44.56 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Allitinib 897383-62-9 Angiogenesis JAK/STAT signaling Tyrosine Kinase/Adaptors EGFR anilino-quinazoline Inhibitor anti-cancer Epidermal growth factor receptor ALS1306 Irreversible HER1 AST-1306 inhibit ErbB-1 AST1306 ALS-1306 ALS 1306 AST 1306 inhibitor