Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Alvimopan (LY 246736) is a synthetic trans-3, 4-dimethyl-4-(3-hydroxyphenyl) piperidine with peripherally selective opioid mu receptor antagonist activity. Alvimopan is a selective and competitive antagonist at mu-opioid receptors, found in myenteric and submucosal neurons and the immune cells of the lamina propria in the human gut. Upon administration, this agent binds to mu-opioid receptors in the gut, thereby reversing opioid-related disturbances in gut motility. Alvimopan is approximately three to nine times more potent than naloxone.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 45.00 | |
2 mg | In stock | $ 63.00 | |
5 mg | In stock | $ 90.00 | |
10 mg | In stock | $ 142.00 | |
25 mg | In stock | $ 268.00 | |
50 mg | In stock | $ 397.00 | |
100 mg | In stock | $ 589.00 | |
500 mg | In stock | $ 1,280.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 90.00 |
Description | Alvimopan (LY 246736) is a synthetic trans-3, 4-dimethyl-4-(3-hydroxyphenyl) piperidine with peripherally selective opioid mu receptor antagonist activity. Alvimopan is a selective and competitive antagonist at mu-opioid receptors, found in myenteric and submucosal neurons and the immune cells of the lamina propria in the human gut. Upon administration, this agent binds to mu-opioid receptors in the gut, thereby reversing opioid-related disturbances in gut motility. Alvimopan is approximately three to nine times more potent than naloxone. |
Targets&IC50 | μ opioid receptor:0.77 nM(Ki), δ opioid receptor:4.4 nM, δ opioid receptor:4.4 nM(Ki), κ opioid receptor:40 nM(Ki) |
Molecular Weight | 424.53 |
Formula | C25H32N2O4 |
CAS No. | 156053-89-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 80 mg/mL(188.4 mM)
You can also refer to dose conversion for different animals. More
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Alvimopan 156053-89-3 Endocrinology/Hormones GPCR/G Protein Neuroscience Opioid Receptor μ-opioid inhibit ADL 8-2698 ileus Inhibitor LY-246736 LY246736 LY 246736 postoperative inhibitor