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Alvimopan

Alvimopan
Alvimopan (LY 246736) is a synthetic trans-3, 4-dimethyl-4-(3-hydroxyphenyl) piperidine with peripherally selective opioid mu receptor antagonist activity. Alvimopan is a selective and competitive antagonist at mu-opioid receptors, found in myenteric and submucosal neurons and the immune cells of the lamina propria in the human gut. Upon administration, this agent binds to mu-opioid receptors in the gut, thereby reversing opioid-related disturbances in gut motility. Alvimopan is approximately three to nine times more potent than naloxone.
Catalog No. T1242Cas No. 156053-89-3
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Purity:99.97%
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Alvimopan

Purity: 99.97%
Catalog No. T1242Cas No. 156053-89-3

Alvimopan (LY 246736) is a synthetic trans-3, 4-dimethyl-4-(3-hydroxyphenyl) piperidine with peripherally selective opioid mu receptor antagonist activity. Alvimopan is a selective and competitive antagonist at mu-opioid receptors, found in myenteric and submucosal neurons and the immune cells of the lamina propria in the human gut. Upon administration, this agent binds to mu-opioid receptors in the gut, thereby reversing opioid-related disturbances in gut motility. Alvimopan is approximately three to nine times more potent than naloxone.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
1 mg$45In Stock
2 mg$63In Stock
5 mg$90In Stock
10 mg$142In Stock
25 mg$268In Stock
50 mg$397In Stock
100 mg$589In Stock
500 mg$1,280In Stock
1 mL x 10 mM (in DMSO)$90In Stock
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Product Introduction

Bioactivity
Description
Alvimopan (LY 246736) is a synthetic trans-3, 4-dimethyl-4-(3-hydroxyphenyl) piperidine with peripherally selective opioid mu receptor antagonist activity. Alvimopan is a selective and competitive antagonist at mu-opioid receptors, found in myenteric and submucosal neurons and the immune cells of the lamina propria in the human gut. Upon administration, this agent binds to mu-opioid receptors in the gut, thereby reversing opioid-related disturbances in gut motility. Alvimopan is approximately three to nine times more potent than naloxone.
Targets&IC50
δ opioid receptor:4.4 nM, δ opioid receptor:4.4 nM(Ki), μ opioid receptor:0.77 nM(Ki), κ opioid receptor:40 nM(Ki)
Chemical Properties
Molecular Weight424.53
FormulaC25H32N2O4
Cas No.156053-89-3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 80 mg/mL (188.4 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.3555 mL11.7777 mL23.5555 mL117.7773 mL
5 mM0.4711 mL2.3555 mL4.7111 mL23.5555 mL
10 mM0.2356 mL1.1778 mL2.3555 mL11.7777 mL
20 mM0.1178 mL0.5889 mL1.1778 mL5.8889 mL
50 mM0.0471 mL0.2356 mL0.4711 mL2.3555 mL
100 mM0.0236 mL0.1178 mL0.2356 mL1.1778 mL

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