ileus

AS-35 is an orally available, selective and potent leukotrienes antagonist that inhibits LTC4, LTD4 and LTE4-induced ileus contractions.AS-35 has antiallergic properties and inhibits leukotriene synthesis.

Alvimopan (LY 246736) is a synthetic trans-3, 4-dimethyl-4-(3-hydroxyphenyl) piperidine with peripherally selective opioid mu receptor antagonist activity. Alvimopan is a selective and competitive antagonist at mu-opioid receptors, found in myenteric and submucosal neurons and the immune cells of the lamina propria in the human gut. Upon administration, this agent binds to mu-opioid receptors in the gut, thereby reversing opioid-related disturbances in gut motility. Alvimopan is approximately three to nine times more potent than naloxone.

Alvimopan dihydrate (ADL 8-2698 dihydrate) is a potent, selective, orally active and reversible μ-opioid receptor antagonist, with an IC 50 of 1.7 nM. Alvimopan dihydrate is highly selective for μ-opioid receptor ( Ki =0.47 nM) over κ- and δ-opioid receptors ( Kis =100, 12 nM, respectively). Alvimopan dihydrate can be used for the research of postoperative ileus [1] [2] [3].