Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Amitriptyline (MK-230, N-750, Ro41575) is a tricyclic antidepressant (TCA) with analgesic properties. Amitriptyline is widely used to treat depression and neuropathic pain.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
10 mg | In stock | $ 39.00 | |
25 mg | In stock | $ 62.00 | |
50 mg | In stock | $ 91.00 | |
100 mg | In stock | $ 133.00 | |
200 mg | In stock | $ 198.00 |
Description | Amitriptyline (MK-230, N-750, Ro41575) is a tricyclic antidepressant (TCA) with analgesic properties. Amitriptyline is widely used to treat depression and neuropathic pain. |
Targets&IC50 | SERT:3.45 nM (ki), 5-HT2:235 nM (ki), σ1 receptor:287 nM (ki), H1 receptor:0.5 nM (ki), NET:13.3 nM (ki), H4 receptor:7.31 nM (ki) |
In vitro | Amitriptyline inhibits both serotonin transporter (SERT) and norepinephrine transporter (NET) with Ki of 3.45 nM and 13.3 nM, respectively. Amitriptyline is also an inhibitor of histamine receptor H1, histamine receptor H4, 5-HT2 and sigma 1 receptor with Ki of 0.5 nM, 7.31 nM, 235 nM and 287 nM, respectively. |
Molecular Weight | 277.4 |
Formula | C20H23N |
CAS No. | 50-48-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 9.7 mg/mL (34.96 mM)
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Amitriptyline 50-48-6 GPCR/G Protein Immunology/Inflammation Neuroscience Sigma receptor 5-HT Receptor Histamine Receptor Norepinephrine inhibitor inhibit