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Amitriptyline hydrochloride

Catalog No. T0678 CAS 549-18-8

Synonyms: Amitriptyline HCl, Tryptizol, Domical, Annoyltin

Amitriptyline hydrochloride (Annoyltin) is the hydrochloride salt of the tricyclic dibenzocycloheptadiene amitriptyline with antidepressant and antinociceptive activities.

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Amitriptyline hydrochloride Chemical Structure

Amitriptyline hydrochloride, CAS 549-18-8

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500 mg	In stock	$ 45.00
1 g	In stock	$ 53.00

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Purity: 99.87%

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Description	Amitriptyline hydrochloride (Annoyltin) is the hydrochloride salt of the tricyclic dibenzocycloheptadiene amitriptyline with antidepressant and antinociceptive activities.
Targets&IC50	5-HT2:235 nM, σ1 receptor:287 nM, Norepinephrine receptor:13.3 nM, 5-HT4:7.31 nM, 5-HT receptor:3.45 nM
In vitro	Amitriptyline inhibits Forskolin-stimulated cyclic AMP accumulation with EC50 values of 16.2 μM in intact CHO/DOR cells. Amitriptyline causes a concentration-dependent stimulation of ERK1/2 and GSK-3β phosphorylation with EC50 values of 9.0 μM in CHO/DOR cells. Amitriptyline (15 μM) causes a stimulation of ERK1/2 phosphorylation in C6 cells. Amitriptyline (30 μM) inhibits Forskolin-stimulated adenylyl cyclase activity and antagonizes ( )-U50,488 inhibitory effect in rat nucleus accumbens. [5] Amitriptyline binds the extracellular domain of both TrkA and TrkB and promotes TrkA-TrkB receptor heterodimerization. Amitriptyline (< 500 nM) promotes TrkA autophosphorylation in primary neurons and induces neurite outgrowth in PC12 cells. Amitriptyline selectively protects T17 cells from apoptosis with EC50 of 50 nM. [6]
In vivo	Amitriptyline (15 mg/kg, i.p.) activates TrkA and TrkB receptors and significantly reduces kainic acid-triggered neuronal cell death in mice. [6] Amitriptyline (15 mg/kg and 30 mg/kg, i.p.) dose-dependently decreases the immobility time in the forced swimming test (FST) of mice. Amitriptyline (15 mg/kg, i.p.) shows a significant 24-h rhythm in the immobility time in the forced swimming test (FST) of mice. [7] Amitriptyline (1 mg/kg and 3 mg/kg) significantly increases the total distance travelled of mice in novel cages. Amitriptyline (10 mg/kg p.o., twice daily) considerably attenuates the hypothermic response to 8-OHDPAT and mCPP in mice. Amitriptyline (10 mg/kg p.o., twice daily) significantly reduces serotonin transporter density by approximately 20% in cortex of mice. [8]

Synonyms	Amitriptyline HCl, Tryptizol, Domical, Annoyltin
Molecular Weight	313.86
Formula	C20H24ClN
CAS No.	549-18-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 59 mg/mL (188 mM)

H2O: 12 mg/mL (38.2 mM)

Ethanol: 59 mg/mL (188 mM)

References and Literature

1. Vaishnavi SN, et al. Biol Psychiatry, 2004, 55(3), 320-322. 2. Nguyen T, et al. Mol Pharmacol, 2001, 59(3), 427-433. 3. Rauser L, et al. J Pharmacol Exp Ther, 2001, 299(1), 83-89. 4. Werling LL, et al. Exp Neurol, 2007, 207(2), 248-257. 5. Onali P, et al. J Pharmacol Exp Ther, 2010, 332(1), 255-265.

Related compound libraries

This product is contained In the following compound libraries：

Tyrosine Kinase Inhibitor Library Anti-Cancer Clinical Compound Library Anti-Cancer Approved Drug Library Drug Repurposing Compound Library Inhibitor Library Anti-Neurodegenerative Disease Compound Library Kinase Inhibitor Library Anti-Cancer Drug Library FDA-Approved Kinase Inhibitor Library GPCR Compound Library

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GNF-8625 monopyridin-N-piperazine hydrochloride Repotrectinib CH7057288 ENT-C225 Altiratinib Entrectinib URMC-099 PF-03814735

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Keywords

Amitriptyline hydrochloride 549-18-8 GPCR/G Protein Immunology/Inflammation Membrane transporter/Ion channel Neuroscience Tyrosine Kinase/Adaptors Sodium Channel Adrenergic Receptor Norepinephrine AChR Histamine Receptor Trk receptor 5-HT Receptor Sigma receptor Serotonin Transporter Amitriptyline HCl Muscarinic acetylcholine receptor Amitriptyline Hydrochloride Beta Receptor psychiatric Inhibitor SERT diseases Serotonin Receptor Tryptizol neuropathic 5-HTT mAChR TrkA/TrkB SLC6A4 Domical depression inhibit Trk Receptor Tropomyosin related kinase receptor Na channels Na+ channels pain heterodimerization 5-hydroxytryptamine Receptor neurologic neurotrophins Amitriptyline Annoyltin inhibitor

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