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Ampicillin sodium

Catalog No. T6386 CAS 69-52-3

Synonyms: Domicillin, D-(-)-α-Aminobenzylpenicillin sodium salt, Penialmen, Citteral

Ampicillin Sodium is the sodium salt form of ampicillin, a broad-spectrum semisynthetic derivative of aminopenicillin. Ampicillin sodium (Domicillin) inhibits bacterial cell wall synthesis by binding to penicillin binding proteins, thereby inhibiting peptidoglycan synthesis, a critical component of the bacterial cell wall.

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Ampicillin sodium, CAS 69-52-3

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Purity: 99.87%

Purity: 98.07%

Purity: 97.34%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Ampicillin Sodium is the sodium salt form of ampicillin, a broad-spectrum semisynthetic derivative of aminopenicillin. Ampicillin sodium (Domicillin) inhibits bacterial cell wall synthesis by binding to penicillin binding proteins, thereby inhibiting peptidoglycan synthesis, a critical component of the bacterial cell wall.
In vitro	Belonging to the penicillin group of beta-lactam antibiotics, ampicillin is able to penetrate Gram-positive and some Gram-negative bacteria. Ampicillin acts as a competitive inhibitor of the enzyme transpeptidase, which is needed by bacteria to make their cell walls. Ampicillin inhibits the third and final stage of bacterial cell wall synthesis in binary fission, which ultimately leads to cell lysis.
In vivo	Ampicillin has been shown to effectively alleviate symptoms of hemorrhagic enteritis in 11-week-old pigs [3] and achieves peak bile concentrations twice that of serum levels. Following oral administration, its concentration in portal blood is double that found in peripheral blood [4]. Furthermore, ampicillin offers neuroprotective benefits against ischemia-reperfusion brain injury by diminishing MMP activities and elevating GLT-1 expression levels. Pretreatment with ampicillin also significantly mitigates medial hippocampal cell death after global forebrain ischemia [5].

Synonyms	Domicillin, D-(-)-α-Aminobenzylpenicillin sodium salt, Penialmen, Citteral
Molecular Weight	371.39
Formula	C16H18N3NaO4S
CAS No.	69-52-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 68 mg/mL (183.1 mM)

Ethanol: 69 mg/mL (185.8 mM)

DMSO: 35 mg/mL (94.2 mM)

References and Literature

1. Sutcliffe JG, et al. Proc Natl Acad Sci U S A, 1978, 75(8), 3737-3741. 2. Gotz V, et al. Am J Hosp Pharm, 1979, 36(6), 754-757. 3. Chopra SL, et al. Effect of Ampicillin on E. Coli of Swine Origin. Can J Comp Med Vet Sci. 1963 Sep;27(9):223-7. 4. Lund B, et al. Ampicillin in portal and peripheral blood and bile after oral administration of ampicillin andpivampicillin. Eur J Clin Pharmacol. 1974;7(2):133-5. 5. Lee KE, et al. The neuroprotective mechanism of ampicillin in a mouse model of transient forebrain ischemia. Korean J Physiol Pharmacol. 2016 Mar;20(2):185-92.

Citations

1. Zhang Z, Ye J, Liu X, et al.Huangqi Guizhi Wuwu decoction alleviates oxaliplatin-induced peripheral neuropathy via the gut-peripheral nerve axis.Chinese Medicine.2023, 18(1): 1-15. 2. Zhou J, Huang J, Huang H, et al.Fiber-integrated cantilever-based nanomechanical biosensors as a tool for rapid antibiotic susceptibility testing.Biomedical Optics Express.2023, 14(5): 1862-1873.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Drug Repurposing Compound Library Anti-Bacterial Compound Library Covalent Inhibitor Library FDA-Approved & Pharmacopeia Drug Library Bioactive Compound Library Bioactive Compounds Library Max Orally Active Compound Library Approved Drug Library Beta-Lactam Compound Library

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Keywords

Ampicillin sodium 69-52-3 Microbiology/Virology Antibiotic Antibacterial inhibit Inhibitor Bacterial Domicillin D-a-Aminobenzylpenicillin sodium Ampicillin D-(-)-α-Aminobenzylpenicillin sodium salt Penialmen D-α-Aminobenzylpenicillin sodium D-alpha-Aminobenzylpenicillin sodium Citteral inhibitor

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