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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $30 | In Stock | |
2 mg | $43 | In Stock | |
5 mg | $68 | In Stock | |
10 mg | $101 | In Stock | |
25 mg | $180 | In Stock | |
50 mg | $288 | In Stock | |
100 mg | $450 | In Stock | |
500 mg | $987 | In Stock |
Description | Autophinib is a potent autophagy inhibitor with a novel chemotype with IC50 values of 90 and 40 nM for autophagy in starvation induced autophagy assay and rapamycin induced autophagy assay. |
In vitro | Autophinib targets VPS34 but not other lipid kinases, mTOR and TBK1. Autophinib appears to be ATP-competitive, targets VPS34 in cell lysate and induces cellular phenotypes consistent with VPS34 inhibition. Autophinib inhibits the accumulation of autophagosomes under fed as well as starved conditions, but does not affect the number of autolysosomes. Thus it is not a late stage autophagy inhibitor but an inhibitor of autophagosome formation. |
Cell Research | Cell lines: HeLa cellsConcentrations: 30 μMIncubation Time: 18 hMethod: |
Molecular Weight | 346.73 |
Formula | C14H11ClN6O3 |
Cas No. | 1644443-47-9 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | Ethanol: < 1 mg/mL (insoluble or slightly soluble) DMSO: <1 mg/mL (insoluble or slightly soluble) ![]() H2O: < 1 mg/mL (insoluble or slightly soluble) |
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