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Azeliragon

Catalog No. T2507 CAS 603148-36-3

Synonyms: 阿齐瑞格, TTP488

Azeliragon is an antagonist at the Receptor for Advanced Glycation End products; is evaluated as a potential treatment for patients with mild-to-moderate Alzheimer_acute_s disease (AD).

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Azeliragon, CAS 603148-36-3

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Azeliragon is an antagonist at the Receptor for Advanced Glycation End products; is evaluated as a potential treatment for patients with mild-to-moderate Alzheimer_acute_s disease (AD).

Kinase Assay

Recombinant Kinase Assays [1]: The ability of AZD5438 to inhibit cdk activity is examined using a scintillation proximity assay with recombinant cdk-cyclin complexes of cyclin-Ecdk2, cdk2-cyclin A, cdk4-cyclin D, and recombinant retinoblastoma substrate (amino acids 792-928) or cdk1-cyclin B1 with a peptide substrate derived from the in vitro p34cdc2 phosphorylation site of histone H1 (biotin-X-Pro-Lys-Thr-Pro-Lys-Lys-Ala-Lys-Lys-Leu). The activity of AZD5438 against recombinant cdk5/p25 (at 2 μM ATP) is determined in a scintillation proximity assay-based assay using peptide substrate (AKKPKTPKKAKKLOH). Inhibition of glycogen synthase kinase 3β activity is determined with scintillation proximity assay based on the use of human purified glycogen synthase kinase 3βenzyme and eukaryotic initiation factor 2B substrate (at 1 μM ATP). AZD5438 is screened against active recombinant human cdk6-cyclin D3, cdk7-cyclin H/MAT1 (cdk activating kinase complex), and cdk9-cyclin T using the kinase selectivity screening service.

Synonyms	阿齐瑞格, TTP488
Molecular Weight	532.13
Formula	C32H38ClN3O2
CAS No.	603148-36-3

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 10 mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Burstein AH, et al. BMC Neurol. 2014 Jan 15;14:12.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library Preclinical Compound Library Inhibitor Library Immunology/Inflammation Compound Library Anti-Alzheimer's Disease Compound Library Drug Repurposing Compound Library Anti-Cancer Active Compound Library Neuronal Signaling Compound Library CNS-Penetrant Compound Library Anti-Cancer Drug Library

Related Products

Related compounds with same targets

4'-Methoxyresveratrol FPS-ZM1 Azeliragon Ipriflavone

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Keywords

Azeliragon 603148-36-3 其他神经科学 advanced glycation end products Beta Amyloid Abeta PF 04494700 Amyloid-β TTP-488 inhibit PF04494700 PF-04494700 β-amyloid peptide TTP488 Inhibitor TTP 488 inhibitor

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