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Azelnidipine

Catalog No. T0121 CAS 123524-52-7

Synonyms: CS 905, UR-12592

Azelnidipine (UR-12592) is a dihydropyridine used as calcium channel blocker.

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Azelnidipine, CAS 123524-52-7

Pack Size	Availability	Price/USD
5 mg	In stock	$ 46.00
10 mg	In stock	$ 62.00
25 mg	In stock	$ 111.00
50 mg	In stock	$ 181.00
100 mg	In stock	$ 326.00
200 mg	In stock	$ 527.00
500 mg	In stock	$ 842.00
1 mL * 10 mM (in DMSO)	In stock	$ 68.00

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Purity: 100%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Azelnidipine (UR-12592) is a dihydropyridine used as calcium channel blocker.

In vivo

Studies indicate that Azelnidipine, as a new-generation calcium channel blocker, can treat hypertension regardless of the patient's risk for ischemic heart disease. This novel, long-acting calcium channel blocker exhibits unique pharmacological properties, such as a slower heart rate and high affinity for vascular tissue, distinguishing it from other calcium channel blockers. Additionally, the high lipophilicity of Azelnidipine allows it to remain active in the vascular wall even after being cleared from the bloodstream.

Synonyms	CS 905, UR-12592
Molecular Weight	582.65
Formula	C33H34N4O6
CAS No.	123524-52-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: 7 mg/mL (12.01 mM)

DMSO: 108 mg/mL (185.4 mM)

References and Literature

1. Kuramoto K, et al. Hypertens Res, 2003, 26(3), 201-208. 2. Wang N, et al. Int J Pharm, 2008, 351(1-2), 55-60. 3. Pan X, Li R, Guo H, et al. Dihydropyridine Calcium Channel Blockers Suppress the Transcription of PD-L1 by Inhibiting the Activation of STAT1[J]. Frontiers in Pharmacology. 2021, 11: 2233.

Citations

1. Pan X, Li R, Guo H, et al. Dihydropyridine Calcium Channel Blockers Suppress the Transcription of PD-L1 by Inhibiting the Activation of STAT1. Frontiers in Pharmacology. 2021 Jan 13;11:539261. doi: 10.3389/fphar.2020.539261. eCollection 2020.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Anti-Cancer Drug Library Inhibitor Library Anti-Cancer Approved Drug Library Anti-Cancer Clinical Compound Library Membrane Protein-targeted Compound Library FDA-Approved & Pharmacopeia Drug Library Anti-Cancer Compound Library Clinical Compound Library Approved Drug Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Azelnidipine 123524-52-7 Membrane transporter/Ion channel Metabolism Calcium Channel CS 905 Ca channels inhibit CS905 CS-905 UR12592 Inhibitor Ca2+ channels UR 12592 UR-12592 inhibitor

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