Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BC1618 (2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]-) is an orally active Fbxo48 inhibitory compound, stimulates Ampk-dependent signaling. It promotes mitochondrial fission, facilitates autophagy and improves hepatic insulin sensitivity.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 30.00 | |
5 mg | In stock | $ 76.00 | |
10 mg | In stock | $ 122.00 | |
25 mg | In stock | $ 247.00 | |
50 mg | In stock | $ 422.00 | |
100 mg | In stock | $ 628.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 84.00 |
Description | BC1618 (2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]-) is an orally active Fbxo48 inhibitory compound, stimulates Ampk-dependent signaling. It promotes mitochondrial fission, facilitates autophagy and improves hepatic insulin sensitivity. |
In vivo | BC1618, whose potency in stimulating Ampk-dependent signaling greatly exceeds 5-aminoimidazole-4-carboxamide-1-β-ribofuranoside (AICAR) or metformin.?This compound increases the biological activity of Ampk not by stimulating the activation of Ampk, but rather by preventing activated pAmpkα from Fbxo48-mediated degradation.?Consistenting with augmenting Ampk activity, BC1618 promotes mitochondrial fission, facilitates autophagy and improves hepatic insulin sensitivity in high-fat-diet-induced obese mice[1]. |
Synonyms | 2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]- |
Molecular Weight | 415.45 |
Formula | C24H24F3NO2 |
CAS No. | 2222094-18-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (240.70 mM), sonification is recommended.
You can also refer to dose conversion for different animals. More
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BC1618 2222094-18-8 Autophagy Chromatin/Epigenetic Others PI3K/Akt/mTOR signaling Ubiquitination E1/E2/E3 Enzyme Mitophagy AMPK Ubiquitin activating enzyme Mitochondrial Autophagy fission inhibit 2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]- Inhibitor mTORC Ubiquitin ligase E1 activating enzyme AMP-activated protein kinase BC-1618 Ubiquitin conjugating enzyme Fbxo48 LPS metformin E3 ligating enzyme pAmpk pS6 mitochondrial BC 1618 insulin E2 conjugating enzyme inhibitor