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Bempedoic acid

Catalog No. T3625 CAS 738606-46-7

Synonyms: ETC1002, ESP-55016, ETC 1002, ETC-1002

Bempedoic acid (ETC1002) is an orally available, once-daily LDL-C lowering small molecule designed to lower elevated levels of LDL-C and to avoid side effects associated with existing LDL-C lowering therapies. Bempedoic acid(ETC1002) is absorbed rapidly in the small intestine and enters the liver through cell surface receptors different from those transporters that selectively take up statins. Bempedoic acid(ETC1002) is a regulator of lipid and carbohydrate metabolism.

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Bempedoic acid, CAS 738606-46-7

Pack Size	Availability	Price/USD
2 mg	In stock	$ 30.00
5 mg	In stock	$ 48.00
10 mg	In stock	$ 67.00
25 mg	In stock	$ 127.00
50 mg	In stock	$ 229.00
100 mg	In stock	$ 369.00
500 mg	In stock	$ 885.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 99.94%

Purity: 99.9%

Purity: 99.84%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Bempedoic acid (ETC1002) is an orally available, once-daily LDL-C lowering small molecule designed to lower elevated levels of LDL-C and to avoid side effects associated with existing LDL-C lowering therapies. Bempedoic acid(ETC1002) is absorbed rapidly in the small intestine and enters the liver through cell surface receptors different from those transporters that selectively take up statins. Bempedoic acid(ETC1002) is a regulator of lipid and carbohydrate metabolism.
In vitro	ETC-1002 is an inactivated prodrug that is transformed into its activated form, an ACL inhibitor (activated state, ETC-1002-CoA), through endogenous liver ACS activity in vivo. It inhibits the migration of leukocytes to the peritoneal cavity of mice induced by sulfatide. Additionally, ETC-1002 restores the activity of lipid AMPK and reduces the phosphorylation of JNK in diet-induced obesity mouse models, leading to a decrease in the expression of the macrophage-specific marker 4F/80.
In vivo	The mechanism of action of TC-1002 primarily targets two liver enzymes: ATP-citrate lyase (ACL) and AMP-activated protein kinase (AMPK), inhibiting the synthesis of steroids and fatty acids while promoting the oxidation of mitochondrial long-chain fatty acids. ETC-1002 enhances AMPK phosphorylation levels, reduces the activity of MAPKs, and diminishes the production of pro-inflammatory cytokines and chemokines.
Kinase Assay	7.5× compounds are added to a 96-well PolyPlate containing 60 μL of Buffer per well with substrates CoA (200 μM), ATP (400 μM), and [14C]citrate. Reaction is started with 4 μL (300 ng/well) ACL, and the plate is incubated at 37°C for 3 h. Th
Cell Research	Primary rat hepatocytes and differentiated human MDMs are treated with indicated concentrations of ETC-1002 for 12 h. Working solutions of ETC-1002 are prepared in serum-free RPMI 1640 containing 12 mM HEPES, 10,000 U/ml penicillin, and 100 μg/ml streptomycin. (Only for Reference)

Synonyms	ETC1002, ESP-55016, ETC 1002, ETC-1002
Molecular Weight	344.49
Formula	C19H36O5
CAS No.	738606-46-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 63 mg/mL (182.9 mM)

References and Literature

1. Nikolic D, et al. Atherosclerosis. 2014, 237(2):705-710. 2. Filippov S, et al. J Lipid Res. 2013, 54(8):2095-2108. 3. Pinkosky SL, et al. J Lipid Res. 2013, 54(1):134-151.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Drug Library Drug Repurposing Compound Library Kinase Inhibitor Library FDA-Approved Kinase Inhibitor Library EMA Approved Drug Library Inhibitor Library Anti-Cancer Clinical Compound Library Anti-Cancer Approved Drug Library Glutamine Metabolism Compound Library ReFRAME Related Library

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Related compounds with same targets

Forrestiacids K Forrestiacids J MEDICA16 (-)-Hydroxycitric acid lactone 2-Furoic acid Hydroxycitric acid tripotassium hydrate (-)-Hydroxycitric acid NDI-091143

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Keywords

Bempedoic acid 738606-46-7 Chromatin/Epigenetic Metabolism PI3K/Akt/mTOR signaling AMPK ATP Citrate Lyase ESP 55016 inhibit Inhibitor ESP55016 AMP-activated protein kinase ETC1002 ACLY ESP-55016 ETC 1002 ETC-1002 inhibitor

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