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CEP-37440

Catalog No. T2655Cas No. 1391712-60-9
Alias CEP37440

CEP-37440 is an effective and specific Dual FAK/ALK inhibitor with IC50s of 120 nM(ALK cellular in 75% human plasma) and 2.3 nM (FAK).

CEP-37440

CEP-37440

Purity: 99.98%
Catalog No. T2655Alias CEP37440Cas No. 1391712-60-9
CEP-37440 is an effective and specific Dual FAK/ALK inhibitor with IC50s of 120 nM(ALK cellular in 75% human plasma) and 2.3 nM (FAK).
Pack SizePriceAvailabilityQuantity
1 mg$31In Stock
2 mg$44In Stock
5 mg$72In Stock
10 mg$128In Stock
25 mg$269In Stock
50 mg$513In Stock
100 mg$746In Stock
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Purity:99.98%
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Product Introduction

Bioactivity
Description
CEP-37440 is an effective and specific Dual FAK/ALK inhibitor with IC50s of 120 nM(ALK cellular in 75% human plasma) and 2.3 nM (FAK).
Targets&IC50
FAK:2.3 nM, ALK:120 nM
Kinase Assay
Kinase assay: Inhibitory potency of GSK2656157 is measured using recombinant GST-PERK (536–1116 amino acids) with 6-His-full-length human eIF2a as a substrate. Kinase selectivity is evaluated using 27 kinases at GSK as well as a panel of 300 kinases.
AliasCEP37440
Chemical Properties
Molecular Weight580.12
FormulaC30H38ClN7O3
Cas No.1391712-60-9
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 2.2 mg/mL (3.79 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.7238 mL8.6189 mL17.2378 mL86.1891 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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