Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CID 2011756 is an ATP-competitive and specific PKD1 inhibitor.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 39.00 | |
10 mg | In stock | $ 72.00 | |
25 mg | In stock | $ 137.00 | |
50 mg | In stock | $ 247.00 | |
100 mg | In stock | $ 342.00 | |
500 mg | In stock | $ 827.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 43.00 |
Description | CID 2011756 is an ATP-competitive and specific PKD1 inhibitor. |
Targets&IC50 | PKD1:3.2 μM, PKD2:0.6 μM, PKD3:0.7 μM |
Kinase Assay | Ub-PLA2 assay: Recombinant enzymes in 20 mM Tris-HCl, pH 8.0, 2 mM CaCl2 and 2 mM β-mercaptoethanol (DUB assay buffer) are preincubated with single doses or dose ranges of PR-619 or P22077 for 30 minutes in a 96 well plate before the addition of Ub-PLA2 and NBD C6-HPC. The liberation of a fluorescent product within the linear range of the assay is monitored at room temperature using a fluorescence plate reader. Vehicle (2%(v/v) DMSO) and 10 mM N-ethylmaleimide are included as controls. Where ≥60% inhibition is observed, EC50 values are determined using a sigmoidal dose response equation. |
Synonyms | CID2011756, CID-2011756 |
Molecular Weight | 396.87 |
Formula | C22H21ClN2O3 |
CAS No. | 638156-11-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 19.8 mg/mL(50 mM)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
CID 2011756 638156-11-3 Cell Cycle/Checkpoint Metabolism Serine/threonin kinase inhibit CID2011756 CID-2011756 Protein kinase D Inhibitor PKD inhibitor