Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CK2/ERK8-IN-1 (TMCB) is a dual inhibitor of casein kinase 2 (CK2) (Ki: 0.25 µM) and ERK8 (IC50s: 0.50 μM) with pro-apoptotic efficacy. CK2/ERK8-IN-1 also binds to PIM1, DYRK1A, and HIPK2 (Kis: 8.65 µM, 11.9 µM, and 15.25 µM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 42.00 | |
10 mg | In stock | $ 66.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 48.00 |
Description | CK2/ERK8-IN-1 (TMCB) is a dual inhibitor of casein kinase 2 (CK2) (Ki: 0.25 µM) and ERK8 (IC50s: 0.50 μM) with pro-apoptotic efficacy. CK2/ERK8-IN-1 also binds to PIM1, DYRK1A, and HIPK2 (Kis: 8.65 µM, 11.9 µM, and 15.25 µM). |
Targets&IC50 | CK2:0.25 μM (ki), CK2:0.5 μM, DYRK1A:11.9 μM (ki), HIPK2:15.25 μM (ki), Pim1:8.65 μM (ki), Apoptosis:, ERK8:0.5 μM |
In vitro | In Jurkat cells, CK2/ERK8-IN-1 (Compound K66; 0-50 µM; 24 hours) treatment displays cytotoxic activity[1]. |
Synonyms | TMCB |
Molecular Weight | 534.82 |
Formula | C11H9Br4N3O2 |
CAS No. | 1085822-09-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 16 mg/mL (29.9 mM), Sonification is recommended.
You can also refer to dose conversion for different animals. More
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CK2/ERK8-IN-1 1085822-09-8 Apoptosis Cell Cycle/Checkpoint Chromatin/Epigenetic JAK/STAT signaling MAPK Metabolism Stem Cells Tyrosine Kinase/Adaptors DYRK Casein Kinase Pim ERK TMCB inhibitor inhibit