Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Cl-amidine hydrochloride is an orally active peptidylarginine deminase (PAD) inhibitor (IC50: 5.9 μM for PAD4). Cl-amidine hydrochloride induces apoptosis in cancer cells and it also induces microRNA (miR)-16 in vitro causing cell cycle arrest. Cl-Amidine hydrochloride prevents histone 3 citrullination and neutrophil extracellular trap formation. It improves survival in a murine sepsis model.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 97.00 | |
10 mg | In stock | $ 173.00 | |
25 mg | In stock | $ 349.00 | |
50 mg | In stock | $ 565.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 117.00 |
Description | Cl-amidine hydrochloride is an orally active peptidylarginine deminase (PAD) inhibitor (IC50: 5.9 μM for PAD4). Cl-amidine hydrochloride induces apoptosis in cancer cells and it also induces microRNA (miR)-16 in vitro causing cell cycle arrest. Cl-Amidine hydrochloride prevents histone 3 citrullination and neutrophil extracellular trap formation. It improves survival in a murine sepsis model. |
Targets&IC50 | PAD4:5.9 μM |
In vitro | Cl-amidine, a bioavailable haloacetamidine-based compound, inhibits all the active PAD isozymes with near equal potency (kinact/KI=13,000 M-1 min-1 for PAD4)[1]. The colon cancer cell line (HT29) is relatively resistant to apoptosis caused by Cl-amidine[2]. Cl-amidine (0, 5, 10, 15, 20, 25, 50 μg/mL, 24 hours) induces apoptosis in TK6 lymphoblastoid cells and HT29 colon cancer cells in a dose-dependent manner. |
In vivo | Cl-amidine (5, 25, 75 mg/kg, oral gavage, once daily) causes significant reductions in the histology scores dose-dependently. Cl-amidine (75 mg/kg, ip once daily) inhibits and treats DSS-induced colitis in mice[2]. |
Molecular Weight | 347.24 |
Formula | C14H20Cl2N4O2 |
CAS No. | 1373232-26-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 19.23 mg/mL (55.38 mM), Sonification is recommended.
H2O: 50 mg/mL (143.99 mM), Sonification is recommended.
You can also refer to dose conversion for different animals. More
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Cl-amidine hydrochloride 1373232-26-8 Apoptosis Chromatin/Epigenetic PAD Cl amidine hydrochloride miRNA-16 Protein Arginine Deiminase Cl-amidine inhibit MicroRNA Peptidylarginine Deiminase Cl-amidine Hydrochloride Clamidine hydrochloride Inhibitor miRNA microRNA-16 colitis sepsis miR-16 inhibitor