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DMOG

Catalog No. T1939 CAS 89464-63-1

Synonyms: Dimethyloxalylglycine, Dimethyloxallyl Glycine, Dimethyloxaloylglycine

DMOG (Dimethyloxalylglycine), an antagonist of the α-ketoglutarate cofactor, is an inhibitor for HIF prolyl hydroxylase.

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DMOG, CAS 89464-63-1

Pack Size	Availability	Price/USD
25 mg	In stock	$ 47.00
50 mg	In stock	$ 58.00
100 mg	In stock	$ 90.00
200 mg	In stock	$ 162.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 99.98%

Purity: 98%

Purity: 80.23%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	DMOG (Dimethyloxalylglycine), an antagonist of the α-ketoglutarate cofactor, is an inhibitor for HIF prolyl hydroxylase.
In vitro	DMOG shows only weakly active in the microsomal system, but efficiently suppresses hydroxyproline synthesis in intact cells. [1] DMOG reduces FGF-2-induced proliferation and cyclin A expression by inhibiting prolyl hydroxylase activity in HPASMC. [3]
In vivo	DMOG inhibits endogenous HIF inactivation and induces angiogenesis in the ischaemic skeletal muscles of mice. [2] Up-regulation of hypoxia-inducible factor-1α by DMOG may be the cardioprotective mechanism of ischemic postconditioning in hyperlipidemic rats[4].
Cell Research	To analyze DNA synthesis as an index of cellular proliferation, VSMC are plated in 48-well plates (5,000 per square centimeter) in growth medium, incubated overnight, and serum-deprived (1% FCS) for 24 h. Replicate wells are then stored at −70°C for baseline (day 0) cell counts, and fresh medium with or without growth factors is added to the remaining wells, which are incubated 72-96 h in 20 or 5% O2. Days 0 and 3 or 4 cell counts are determined by lysing cells in a buffer containing a fluorescent dye, which has minimal fluorescence by itself but fluoresces when bound to DNA or RNA. Absolute cell numbers are calculated by comparing the fluorescence of specimens with that of a standard curve similarly prepared using a known number of cells. (Only for Reference)

Synonyms	Dimethyloxalylglycine, Dimethyloxallyl Glycine, Dimethyloxaloylglycine
Molecular Weight	175.14
Formula	C6H9NO5
CAS No.	89464-63-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 17.54mg/mL（100 mM), Sonication is recommended.

DMSO: 17.5 mg/mL(100 mM)

Ethanol: 35 mg/mL (199.84 mM)

References and Literature

1. Baader E, et al. Biochem J. 1994, 300 ( Pt 2), 525-530. 2. Milkiewicz M, et al. J Physiol. 2004, 60(Pt 1), 21-26. 3. Schultz K, et al. Am J Physiol Lung Cell Mol Physiol. 2009, 296(6), L921-927. 4. Li X, et al. Acta Biochim Biophys Sin (Shanghai). 2014, 46(2), 112-118.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Cancer Metabolism Compound Library HIF-1 Signaling Pathway Compound Library Metabolism Compound Library Covalent Inhibitor Library Epigenetics Compound Library Autophagy Compound Library Glycolysis Compound Library Bioactive Compound Library Anti-Pancreatic Cancer Compound Library

Related Products

Related compounds with same targets

Oltipraz BAY 87-2243 dencichine HIF-2α-IN-2 M1001 Citric acid trilithium salt tetrahydrate 1,4-DPCA Ethyl 3,4-dihydroxybenzoate

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

DMOG 89464-63-1 Angiogenesis Autophagy Chromatin/Epigenetic Metabolism HIF/HIF Prolyl-Hydroxylase HIF Dimethyloxalylglycine Dimethyloxallyl Glycine diarrhoea Hypoxia-inducible factors stabilisation Inhibitor accmulation HIFs inhibit HIF-PH pro-angiogenic Dimethyloxaloylglycine inhibitor

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