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Dacarbazine

Catalog No. T1120   CAS 4342-03-4
Synonyms: B cell, Apoptosis, Dacarbazine, Nucleoside Antimetabolite/Analog, inhibit, antineoplastic, Inhibitor, DTIC-Dome, T cell, metastatic malignant melanoma, Imidazole Carboxamide

Dacarbazine is an antineoplastic agent. It has significant activity against melanomas.

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Dacarbazine, CAS 4342-03-4
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Purity: 98%
Biological Description
Chemical Properties
Storage & Solubility Information
Description Dacarbazine is an antineoplastic agent. It has significant activity against melanomas.
In vitro Treatment of Dacarbazine sensitizes melanomas to lysis of peptide-specific CTL and it is is mediated through Fas-independent pathway[2].
In vivo Treatment of combination of Axitinib and DTIC demonstrates significant antitumor activity against melanoma flank xenografts, reduces tumor cell proliferation and decreases the area of tumor necrosis and increases apoptosis. It also reduces meta-tasis-related factors and prolongs lifespan in mice[3].
Cell Research Apotosis assay: UACC903 (UACC) cells treated with or without DTIC (20 μM) for 48 h are incubated with agonist anti-Fas Ab, CH-11 (500 ng/ml), for 5 and 16 h, respectively. To distinguish whether death/apoptosis is mediated by FasR, blocking anti-Fas Ab ZB4 (2 mg/ml) is added in the corresponding groups. At the end of incubation, cells are harvested and stained with propidium iodide and FITC-annexin V (BD PharMingen) for detecting apoptosis according to the instruction provided by the company. Ten thousand cells from each group are collected, and dead and apoptotic cells are analyzed without gating using CellQuest software. (Only for Reference)
Synonyms B cell, Apoptosis, Dacarbazine, Nucleoside Antimetabolite/Analog, inhibit, antineoplastic, Inhibitor, DTIC-Dome, T cell, metastatic malignant melanoma, Imidazole Carboxamide
Molecular Weight 182.187
Formula C6H10N6O
CAS No. 4342-03-4

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

Ethanol: <1 mg/mL

DMSO: 3 mg/mL (16.46 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Serrone L, et al. J Exp Clin Cancer Res. 2000, 19(1):21-34. 2. Yang S, et al. J Immunol. 2004, 172(7):4599-608. 3. Zhang XH, et al. Oncol Lett. 2013, 6(1):69-74.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Compound Library Inhibitor Library Drug-induced Liver Injury (DILI) Compound Library DNA Damage & Repair Compound Library Drug Repurposing Compound Library Anti-Cancer Approved Drug Library Anti-Cancer Active Compound Library FDA-Approved Drug Library Apoptosis Compound Library Epigenetics Compound Library

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