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Deferiprone

Catalog No. T1565 CAS 30652-11-0

Synonyms: Deferidone, CP20

Deferiprone (Deferidone) is an Iron Chelator. The mechanism of action of deferiprone is as an Iron Chelating Activity.

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Deferiprone, CAS 30652-11-0

Pack Size	Availability	Price/USD
500 mg	In stock	$ 42.00
1 g	In stock	$ 50.00
5 g	Inquiry	$ 58.00
1 mL * 10 mM (in DMSO)	In stock	$ 46.00

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Purity: 99.97%

Purity: 99.59%

Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Deferiprone (Deferidone) is an Iron Chelator. The mechanism of action of deferiprone is as an Iron Chelating Activity.
In vitro	Administration of 100 mg/kg Deferiprone resulted in a 24% reduction in the average cross-sectional area of the basilar artery in rabbits. When combined with subarachnoid hemorrhage (SAH), Deferiprone also demonstrated variability in the waviness of the internal elastic lamina in rabbits.
In vivo	At a concentration of 1 mM, Deferiprone causes a significant decrease in complex I-III activity in iron-overloaded cardiomyocytes. It exhibits cytotoxic effects on human tumor cell lines HSC-2, HSC-3, and HL-60, with IC50 values of 13.5 μg/mL, 9.9 μg/mL, and 10.6 μg/mL, respectively. The cytotoxicity of HK1 against HL-60 and HSC-2 cells is reduced in the presence of FeCl3. At 100 μg/mL, Deferiprone induces inter-nucleosomal DNA fragmentation in HL-60 cells, a process inhibited by the addition of FeCl3. Protection of myocytes from doxorubicin-induced lactate dehydrogenase release is observed with 100 μM Deferiprone. It effectively inhibits the transfer of radiolabeled iron from iron-loaded cardiomyocytes and protects or restores mitochondrial respiratory enzyme activity in a xanthine oxidase/hypoxanthine superoxide generating system at a concentration of 0.3 mM. Furthermore, 0.5 mM Deferiprone enhances the clearance of free iron from RBC membranes in a time- and dose-dependent manner. A 3 mM concentration significantly reduces hydroxyl radical production from the iron(III)-adriamycin complex in the xanthine oxidase/hypoxanthine superoxide generating system.

Synonyms	Deferidone, CP20
Molecular Weight	139.15
Formula	C7H9NO2
CAS No.	30652-11-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 7.14 mg/mL (51.31 mM), Sonification is recommended.

H2O: 10 mg/mL (71.86 mM), Sonification is recommended.

References and Literature

1. Barnabé N, et al. Free Radic Biol Med, 2002, 33(2), 266-275. 2. Shalev O, et al. Blood, 1995, 86(5), 22008-22013. 3. Link G, et al. J Lab Clin Med, 1999, 133(2), 179-188. 4. Yasumoto E, et al. Anticancer Res, 2004, 24(2B), 755-762. 5. Arthur AS, et al. Neurosurgery, 1997, 41(6), 1385-1391. 6. Deng F, Xu G, Cheng Z, et al. Hepatitis B Surface Antigen Suppresses the Activation of Nuclear Factor Kappa B Pathway via Interaction With the TAK1-TAB2 Complex[J]. Frontiers in Immunology. 2021, 12: 233.

Citations

1. Deng F, Xu G, Cheng Z, et al. Hepatitis B Surface Antigen Suppresses the Activation of Nuclear Factor Kappa B Pathway via Interaction With the TAK1-TAB2 Complex. Frontiers in Immunology. 2021, 12: 233.

Related compound libraries

This product is contained In the following compound libraries：

EMA Approved Drug Library Drug Repurposing Compound Library Pediatric Drug Library Anti-Viral Compound Library Metabolism Compound Library FDA-Approved & Pharmacopeia Drug Library Bioactive Compounds Library Max Apoptosis Compound Library Target-Focused Phenotypic Screening Library Ferroptosis Compound Library

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Keywords

Deferiprone 30652-11-0 Apoptosis Metabolism Microbiology/Virology Others Proteases/Proteasome Ferroptosis HCV Protease UGT Deferidone HCV inhibit Inhibitor Hepatitis C virus CP20 CP 20 CP-20 inhibitor

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