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Dexpramipexole dihydrochloride

Catalog No. T11011 CAS 104632-27-1

Synonyms: KNS-760704 dihydrochloride, R-(+)-Pramipexole dihydrochloride, (R)-Pramipexole dihydrochloride

Dexpramipexole dihydrochloride (KNS-760704 dihydrochloride) ((R)-Pramipexole dihydrochloride) is a neuroprotective agent and is a weak non-ergoline dopamine agonist.

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Dexpramipexole dihydrochloride Chemical Structure

Dexpramipexole dihydrochloride, CAS 104632-27-1

Pack Size	Availability	Price/USD
5 mg	In stock	$ 44.00
10 mg	In stock	$ 72.00
25 mg	In stock	$ 155.00
50 mg	In stock	$ 263.00
100 mg	In stock	$ 397.00
200 mg	In stock	$ 582.00
1 mL * 10 mM (in DMSO)	In stock	$ 48.00

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Purity: 99.44%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Dexpramipexole dihydrochloride (KNS-760704 dihydrochloride) ((R)-Pramipexole dihydrochloride) is a neuroprotective agent and is a weak non-ergoline dopamine agonist.

In vitro

Dextromethorphan has been found to have neuroprotective effects and is being studied for the treatment of amyotrophic lateral sclerosis (ALS). Dexpramipexole reduces mitochondrial reactive oxygen species (ROS) production, inhibits the activation of apoptosis pathways, and improves cell survival in response to various neurotoxins and β-amyloid neurotoxicity. Compared with the S-(-) isomer, dextromethorphan has lower dopamine agonist activity.

Synonyms	KNS-760704 dihydrochloride, R-(+)-Pramipexole dihydrochloride, (R)-Pramipexole dihydrochloride
Molecular Weight	284.25
Formula	C10H19Cl2N3S
CAS No.	104632-27-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (351.80 mM)

H2O: 100 mg/mL (351.80 mM), Sonification is recommended.

References and Literature

1. Rudnicki SA, Berry JD, Ingersoll E, et al. Dexpramipexole effects on functional decline and survival in subjects with amyotrophic lateral sclerosis in a Phase II study: subgroup analysis of demographic and clinical characteristics. Amyotroph Lateral Scler Frontotemporal Degener. 2013 Jan;14(1):44-51. 2. Alavian KN, Dworetzky SI, Bonanni L, et al. Effects of dexpramipexole on brain mitochondrial conductances and cellular bioenergetic efficiency. Brain Res. 2012 Mar 29;1446:1-11. 3. Cudkowicz M, Bozik ME, Ingersoll EW, et al. The effects of dexpramipexole (KNS-760704) in individuals with amyotrophic lateral sclerosis. Nat Med. 2011 Nov 20;17(12):1652-6. 4. Bozik ME, Mather JL, Kramer WG, et al. Safety, tolerability, and pharmacokinetics of KNS-760704 (dexpramipexole) in healthy adult subjects. J Clin Pharmacol. 2011 Aug;51(8):1177-85. 5. Cheah BC, Kiernan MC. Dexpramipexole, the R(+) enantiomer of pramipexole, for the potential treatment of amyotrophic lateral sclerosis. IDrugs. 2010 Dec;13(12):911-20.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Anti-Neurodegenerative Disease Compound Library GPCR Compound Library Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Bioactive Compound Library Neuronal Signaling Compound Library Bioactive Compounds Library Max Neurotransmitter Receptor Compound Library Antidepressant Compound Library

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Related compounds with same targets

Rotigotine- BP 897 hydrochloride Pimethixene A-381393 Flupentixol dihydrochloride Mirtazapine Buspirone hydrochloride Mianserin hydrochloride

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Keywords

Dexpramipexole dihydrochloride 104632-27-1 GPCR/G Protein Neuroscience Dopamine Receptor inhibit Inhibitor KNS 760704 Dihydrochloride KNS-760704 Dihydrochloride (R)-Pramipexole KNS760704 KNS-760704 dihydrochloride R-(+)-Pramipexole dihydrochloride R-Pramipexole Dihydrochloride Pramipexole Dexpramipexole KNS 760704 Pramipexole Dihydrochloride KNS760704 Dihydrochloride Dexpramipexole Dihydrochloride (R)-Pramipexole dihydrochloride R-Pramipexole KNS-760704 inhibitor

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