Shopping Cart
- Remove All
![TargetMol](https://newstatic.targetmol.com/error/oops.webp)
Your shopping cart is currently empty
Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $39 | In Stock | |
5 mg | $64 | In Stock | |
10 mg | $97 | In Stock | |
25 mg | $162 | In Stock | |
50 mg | $238 | In Stock | |
1 mL x 10 mM (in DMSO) | $70 | In Stock |
Description | Ro 10-5824 dihydrochloride is a selective agonist of dopamine D4 receptor partial, (Ki of 5.2 nM). |
In vitro | RO-10-5824 shows high affinity binding(Ki=5.2±0.9 nM (n=3)), 250-fold selectivity vs human D3R, and >1000 fold selectivity for D4 vs human D2, D1, and D5 receptors. RO-10-5824 stimulates 35S-GTPγS binding (EC50 : 205±67 nM) (n=7) and maximal induction at 36±4% above basal level[2]. |
In vivo | The success rate in the ORD task increased by Ro 10-5824 (3 mg/kg). At doses of 1 and 3 mg/kg, in the frontal cortex, Ro 10-5824 increases baseline gamma band activity. RO-10-5824 (10.0 mg/kg) does not increase center entries in the open field in a single 60-min session without the novel object present, nor does it increase overall transitions in the initial experiment with C57 mice[2]. |
Molecular Weight | 353.29 |
Formula | C17H22Cl2N4 |
Cas No. | 189744-94-3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||||||||||||||||||||||||||||||||
Solubility Information | H2O: 60 mg/mL (169.83 mM) DMSO: 8.33 mg/mL (23.58 mM) | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
H2O/DMSO
H2O
|
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.