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MLS1547
Catalog No. T28073Cas No. 315698-36-3
Alias MLS-1547, MLS000051547, MLS 1547
MLS1547 (MLS000051547) is a highly efficacious agonist of G protein-biased dopamine D2 receptor with a Ki of 1.2 μM. MLS1547 stimulates D2R G protein-mediated signaling with EC50 of 0.37 μM in a calcium mobilization assay.
MLS1547
Catalog No. T28073Alias MLS-1547, MLS000051547, MLS 1547Cas No. 315698-36-3
MLS1547 (MLS000051547) is a highly efficacious agonist of G protein-biased dopamine D2 receptor with a Ki of 1.2 μM. MLS1547 stimulates D2R G protein-mediated signaling with EC50 of 0.37 μM in a calcium mobilization assay.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | $35 | In Stock | |
| 25 mg | $52 | In Stock | |
| 50 mg | Inquiry | In Stock | |
| 1 mL x 10 mM (in DMSO) | $36 | In Stock |
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Purity:98.02%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | MLS1547 (MLS000051547) is a highly efficacious agonist of G protein-biased dopamine D2 receptor with a Ki of 1.2 μM. MLS1547 stimulates D2R G protein-mediated signaling with EC50 of 0.37 μM in a calcium mobilization assay. |
| In vitro | MLS1547 fully antagonizes dopamine-mediated β-arrestin recruitment to the D2 dopamine receptor, with an IC50 of 9.9 μM in the DiscoveRx assay and 3.8 μM in the BRET assay, and completely displaces [3H]methylspiperone binding to the D2 dopamine receptor, with a Ki of 1.2 μM[2]. |
| Alias | MLS-1547, MLS000051547, MLS 1547 |
| Molecular Weight | 354.83 |
| Formula | C19H19ClN4O |
| Cas No. | 315698-36-3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 45 mg/mL (126.82 mM)  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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