Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Diphenyleneiodonium chloride (DPI)(DPI) is an irreversible inhibitor of iNOS and eNOS (IC50 values of 50 nM and 0.3 μM, respectively),and displays broad-spectrum bactericidal activity.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 38.00 | |
10 mg | In stock | $ 61.00 | |
25 mg | In stock | $ 109.00 | |
50 mg | In stock | $ 198.00 | |
100 mg | In stock | $ 343.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 66.00 |
Description | Diphenyleneiodonium chloride (DPI)(DPI) is an irreversible inhibitor of iNOS and eNOS (IC50 values of 50 nM and 0.3 μM, respectively),and displays broad-spectrum bactericidal activity. |
Targets&IC50 | iNOS:50 nM , eNOS:0.3 µM |
In vitro | Diphenyleneiodonium chloride (DPIC), an NADPH/NADH oxidase inhibitor, as possessing potent antimicrobial activity against non-tuberculous mycobacteria.?DPIC exhibited concentration-dependent bactericidal activity against M. fortuitum and synergized with amikacin, ceftriaxone, ceftazidime and meropenem[1]. |
Cell Research | Whole-cell growth inhibition assays were used to screen and identify novel inhibitors. The hit compounds(Diphenyleneiodonium chloride) were tested for cytotoxicity against Vero cells to determine the selectivity index, and time-kill kinetics were determined against Mycobacterium fortuitum. The compound's ability to synergize with amikacin, ceftriaxone, ceftazidime and meropenem was determined using fractional inhibitory concentration indexes followed by its ability to decimate mycobacterial infections ex vivo[1]. |
Synonyms | DPI |
Molecular Weight | 314.55 |
Formula | C12H8ClI |
CAS No. | 4673-26-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 6 mg/mL (19.07 mM)
You can also refer to dose conversion for different animals. More
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Diphenyleneiodonium chloride 4673-26-1 Immunology/Inflammation Membrane transporter/Ion channel Metabolism NF-Κb NADPH Reactive Oxygen Species TRP/TRPV Channel NOS NADPH Oxidase Diphenyleneiodonium inhibit NOX Diphenyleneiodonium Chloride TRP Channel DPI Transient receptor potential channels Inhibitor inhibitor