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Doravirine

Catalog No. T3632 CAS 1338225-97-0

Synonyms: MK-1439

Doravirine (MK-1439) is a non-nucleoside reverse transcriptase inhibitor, used in the treatment of HIV/AIDS.

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Doravirine, CAS 1338225-97-0

Pack Size	Availability	Price/USD
1 mg	In stock	$ 45.00
2 mg	In stock	$ 63.00
5 mg	In stock	$ 98.00
10 mg	In stock	$ 178.00
25 mg	In stock	$ 353.00
50 mg	In stock	$ 547.00
100 mg	In stock	$ 789.00
500 mg	In stock	$ 1,630.00
1 mL * 10 mM (in DMSO)	In stock	$ 133.00

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Purity: 99.79%

Purity: 99.33%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Doravirine (MK-1439) is a non-nucleoside reverse transcriptase inhibitor, used in the treatment of HIV/AIDS.
Targets&IC50	Y181C:31nM, K103N:21nM, Virus (WT):12nM, K103N/Y181C:33 nM
In vitro	Doravirine exhibits potent antiviral activity against wild-type virus and K103N, Y181C, and K103N/Y181C mutant viruses, with IC50 value of 12, 21, 31, and 33 nM, respectively. [1]? MK-1439 exhibited similar antiviral activities against 10 different HIV-1 subtype viruses (a total of 93 viruses).[2]
In vivo	Administration of 50 mg doravirine with a high-fat meal is associated with slight elevations in AUC time zero to infinity (AUC0-∞) and C24 h with no change in Cmax. Midazolam AUC0-∞ is slightly reduced by coadministration of doravirine (geometric mean ratio 0.82, 90% CI 0.70, 0.97). [3]
Kinase Assay	FS-3 substrate is solubilized in assay buffer at 500 μM and frozen at -20°C in single-use aliquots for up to 4 weeks. Recombinant autotaxin is diluted in Tris-buffered saline (140 mM NaCl, 5 mM KCl, 1 mM CaCl2, 1 mM MgCl2, 50 mM Tris, pH 8.0) and incubated with compound in DMSO or DMSO alone (final 1% DMSO) for 15 min at 37°C, and the reaction is started with the addition of FS-3 at a final concentration of 1 μM. The reaction is allowed to proceed at 37°C for 30 min and monitored at 520 nm until the uninhibited control compared with a no-enzyme control gave a Z′≥0.5. IC50s are determined in triplicate by using a four-parameter fit[1].

Synonyms	MK-1439
Molecular Weight	425.75
Formula	C17H11ClF3N5O3
CAS No.	1338225-97-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 30 mg/mL (70.46 mM)

References and Literature

1. Lai MT, et al. Antimicrob Agents Chemother. 2014;58(3):1652-63. 2. Anderson MS, et al. Antivir Ther. 2015;20(4):397-405. 3. Fical L. Vývoj UHPLC-MS/MS metody pro analýzu vybraných antivirotik v HILIC a RP módu[J]. 2020 4. Fical L, Khalikova M, Kočová Vlčková H, et al. Determination of Antiviral Drugs and Their Metabolites Using Micro-Solid Phase Extraction and UHPLC-MS/MS in Reversed-Phase and Hydrophilic Interaction Chromatography Modes[J]. Molecules. 2021, 26(8): 2123.

Citations

1. Fical L, Khalikova M, Kočová Vlčková H, et al. Determination of Antiviral Drugs and Their Metabolites Using Micro-Solid Phase Extraction and UHPLC-MS/MS in Reversed-Phase and Hydrophilic Interaction Chromatography Modes. Molecules. 2021, 26(8): 2123.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library EMA Approved Drug Library Drug Repurposing Compound Library Anti-Infection Compound Library Anti-COVID-19 Compound Library Clinical Compound Library Bioactive Compound Library Target-Focused Phenotypic Screening Library Approved Drug Library Nucleotide Compound Library

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Keywords

Doravirine 1338225-97-0 Microbiology/Virology Proteases/Proteasome HIV Protease Reverse Transcriptase MK1439 inhibit MK 1439 HIV Human immunodeficiency virus Inhibitor MK-1439 inhibitor

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