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ETP-45658

Catalog No. T25399 CAS 1198357-79-7

Synonyms: ETP45658, ETP 45658

ETP-45658 (ETP45658) is a PI 3-kinase inhibitor (IC50 values are 22, 30, 129 and 710 nM for PI 3-Kα, PI 3-Kδ, PI 3-Kβ and PI 3-Kγ respectively). Also inhibits DNA-PK and mTOR (IC50 values are 70.6 and 152 nM respectively).

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

ETP-45658, CAS 1198357-79-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 64.00
2 mg	In stock	$ 90.00
5 mg	In stock	$ 139.00
10 mg	In stock	$ 228.00
25 mg	In stock	$ 428.00
50 mg	In stock	$ 642.00
100 mg	In stock	$ 913.00
500 mg	In stock	$ 1,850.00
1 mL * 10 mM (in DMSO)	In stock	$ 153.00

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Purity: 99.13%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	ETP-45658 (ETP45658) is a PI 3-kinase inhibitor (IC50 values are 22, 30, 129 and 710 nM for PI 3-Kα, PI 3-Kδ, PI 3-Kβ and PI 3-Kγ respectively). Also inhibits DNA-PK and mTOR (IC50 values are 70.6 and 152 nM respectively).
Targets&IC50	mTOR:152.0 nM (IC50), PI3Kγ:717.3 nM (IC50), PI3Kα:22.0 nM (IC50), DNA-PK:70.6 nM (IC50), PI3Kβ:129.0 nM (IC50), PI3Kδ:39.8 nM (IC50)

Synonyms	ETP45658, ETP 45658
Molecular Weight	311.34
Formula	C16H17N5O2
CAS No.	1198357-79-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/ml (192.72 mM)

References and Literature

1. Maswadeh et al (2015) Coadministration of dox. and etop. loaded in camel milk phospholipids liposomes showed increased antitumor activity in a murine model. PLoS One 10 2847 PMID: 25926730 2. Link W, Oyarzabal J, Serelde BG, Albarran MI, Rabal O, Cebriá A, Alfonso P, Fominaya J, Renner O, Peregrina S, Soilán D, Ceballos PA, Hernández AI, Lorenzo M, Pevarello P, Granda TG, Kurz G, Carnero A, Bischoff JR. Chemical interrogation of FOXO3a nuclear translocation identifies potent and selective inhibitors of phosphoinositide 3-kinases. J Biol Chem. 2009 Oct 9;284(41):28392-400. doi: 10.1074/jbc.M109.038984. Epub 2009 Aug 18. PubMed PMID: 19690175; PubMed Central PMCID: PMC2788888.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Metabolism Compound Library Stem Cell Differentiation Compound Library Antidepressant Compound Library Anti-Liver Cancer Compound Library Anti-Colorectal Cancer Compound Library Anti-Pancreatic Cancer Compound Library Anti-Prostate Cancer Compound Library Oxidation-Reduction Compound Library DNA Damage & Repair Compound Library

Related Products

Related compounds with same targets

ETP-46464 OSI-027 Wortmannin NU6027 NU 7026 Pictilisib dimethanesulfonate KU-57788 Onatasertib

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

ETP-45658 1198357-79-7 DNA Damage/DNA Repair PI3K/Akt/mTOR signaling DNA-PK mTOR PI3K Inhibitor breast ETP45658 Mammalian target of Rapamycin DNA-dependent protein kinase inhibit ETP 45658 Phosphoinositide 3-kinase cancer inhibitor

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