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Endoxifen

Catalog No. T4281   CAS 110025-28-0
Synonyms: (E/Z)-N-desmethyl-4-hydroxy Tamoxifen, (E/Z)-Endoxifen

(E/Z)-Endoxifen ((E/Z)-Endoxifen) is an active metabolite of tamoxifen produced by the sequential action of cytochrome P450 (CYP) isoforms, including CYP2D6. It is a strong anti-estrogen, as it has an approximately 100-fold greater affinity for estrogen receptors than tamoxifen. As the efficient conversion of tamoxifen to endoxifen depends on CYP2D6, polymorphisms in this CYP isoform can impact the effectiveness of TMX treatment.

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Endoxifen Chemical Structure
Endoxifen, CAS 110025-28-0
Pack Size Availability Price/USD Quantity
5 mg In stock $ 41.00
10 mg In stock $ 65.00
50 mg In stock $ 231.00
1 mL * 10 mM (in DMSO) In stock $ 83.00
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Purity: 99.66%
Purity: 98.75%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description (E/Z)-Endoxifen ((E/Z)-Endoxifen) is an active metabolite of tamoxifen produced by the sequential action of cytochrome P450 (CYP) isoforms, including CYP2D6. It is a strong anti-estrogen, as it has an approximately 100-fold greater affinity for estrogen receptors than tamoxifen. As the efficient conversion of tamoxifen to endoxifen depends on CYP2D6, polymorphisms in this CYP isoform can impact the effectiveness of TMX treatment.
Synonyms (E/Z)-N-desmethyl-4-hydroxy Tamoxifen, (E/Z)-Endoxifen
Molecular Weight 373.49
Formula C25H27NO2
CAS No. 110025-28-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 27.5 mg/mL (73.63 mM)

TargetMolReferences and Literature

1. Goetz MP, et al. Tamoxifen, endoxifen, and CYP2D6: the rules for evaluating a predictive factor. Oncology (Williston Park). 2009 Dec;23(14):1233-4, 1236. 2. Wu X, et al. The tamoxifen metabolite, endoxifen, is a potent antiestrogen that targets estrogen receptor alpha for degradation in breast cancer cells. Cancer Res. 2009 Mar 1;69(5):1722-7.

TargetMolCitations

1. Wang K, Chen Y, Gao S, et al. Norlichexanthone purified from plant endophyte prevents postmenopausal osteoporosis by targeting ERα to inhibit RANKL signaling[J].. Acta Pharmaceutica Sinica B. 2021, 11(2): 442-455 2. Wang K, Chen Y, Gao S, et al Norlichexanthone purified from plant endophyte prevents postmenopausal osteoporosis by targeting ERα to inhibit RANKL signaling. Acta Pharmaceutica Sinica B. 2020

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Drug Library Anti-Parasitic Compound Library Anti-Cancer Clinical Compound Library Target-Focused Phenotypic Screening Library Clinical Compound Library Anti-Infection Compound Library Endocrinology-Hormone Compound Library Anti-Aging Compound Library Drug Repurposing Compound Library NO PAINS Compound Library

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Keywords

Endoxifen 110025-28-0 Endocrinology/Hormones Metabolism Microbiology/Virology Parasite Aromatase Estrogen Receptor/ERR Estrogen/progestogen Receptor Drug Metabolite inhibit Inhibitor (E/Z)-N-desmethyl-4-hydroxy Tamoxifen (E/Z)-Endoxifen inhibitor

 

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