Powder: -20°C for 3 years | In solvent: -80°C for 1 year
(E/Z)-Endoxifen ((E/Z)-Endoxifen) is an active metabolite of tamoxifen produced by the sequential action of cytochrome P450 (CYP) isoforms, including CYP2D6. It is a strong anti-estrogen, as it has an approximately 100-fold greater affinity for estrogen receptors than tamoxifen. As the efficient conversion of tamoxifen to endoxifen depends on CYP2D6, polymorphisms in this CYP isoform can impact the effectiveness of TMX treatment.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 41.00 | |
10 mg | In stock | $ 65.00 | |
50 mg | In stock | $ 231.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 83.00 |
Description | (E/Z)-Endoxifen ((E/Z)-Endoxifen) is an active metabolite of tamoxifen produced by the sequential action of cytochrome P450 (CYP) isoforms, including CYP2D6. It is a strong anti-estrogen, as it has an approximately 100-fold greater affinity for estrogen receptors than tamoxifen. As the efficient conversion of tamoxifen to endoxifen depends on CYP2D6, polymorphisms in this CYP isoform can impact the effectiveness of TMX treatment. |
Synonyms | (E/Z)-N-desmethyl-4-hydroxy Tamoxifen, (E/Z)-Endoxifen |
Molecular Weight | 373.49 |
Formula | C25H27NO2 |
CAS No. | 110025-28-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 27.5 mg/mL (73.63 mM)
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Endoxifen 110025-28-0 Endocrinology/Hormones Metabolism Microbiology/Virology Parasite Aromatase Estrogen Receptor/ERR Estrogen/progestogen Receptor Drug Metabolite inhibit Inhibitor (E/Z)-N-desmethyl-4-hydroxy Tamoxifen (E/Z)-Endoxifen inhibitor