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Ezetimibe

Catalog No. T1593   CAS 163222-33-1
Synonyms: SCH 58235

Ezetimibe (SCH 58235) is a Dietary Cholesterol Absorption Inhibitor. The physiologic effect of ezetimibe is by means of Decreased Cholesterol Absorption.

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Ezetimibe Chemical Structure
Ezetimibe, CAS 163222-33-1
Pack Size Availability Price/USD Quantity
10 mg In stock $ 41.00
25 mg In stock $ 56.00
50 mg In stock $ 70.00
100 mg In stock $ 89.00
200 mg In stock $ 127.00
500 mg In stock $ 208.00
1 g In stock $ 297.00
1 mL * 10 mM (in DMSO) In stock $ 50.00
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Purity: 99.97%
Purity: 97.28%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Ezetimibe (SCH 58235) is a Dietary Cholesterol Absorption Inhibitor. The physiologic effect of ezetimibe is by means of Decreased Cholesterol Absorption.
Kinase Assay GST-p62 is prepared from Escherichia coli and 0.5 μg of the purified GST-p62 protein is used for in vitro AMPK phosphorylation assay. Phosphorylation of p62 protein by AMPK is determined by non-radioisotope method using γS-ATP. AMPK complex is immuno-purified from the HEK293 cells, to which either myc-AMPKα1 wild-type (WT) or myc-AMPKα1 kinase-dead mutant (KD, D157A) is transfected with Flag-AMPKβ1 and HA-AMPKγ1. AMPK complex is added into the reaction mixture containing 20 mM HEPES, pH7.4, 1 mM EGTA, 0.4 mM EDTA, 5 mM MgCl2, 0.05 mM DTT, 0.5 μg GST-p62, 0.2 mM AMP, and 1 mM ATPγS. Reaction is carried out at 37°C for 30 min, and then terminated by adding 20 mM EDTA. To detect γS-labeled p62 protein, the reaction product is alkylated with 2.5 mM PNBM for 2 h at room temperature and analyzed the products by western blotting using anti-thiophosphate antibody[1].
Cell Research Ezetimibe is dissolved in DMSO and stored, and then diluted with appropriate medium before use[2]. Huh7 human hepatocytes are cultured in high glucose DMEM containing 10% FBS, 100 units/mL penicillin and 100 μg/mL streptomycin at 37°C in a 95% air/5% CO2 atmosphere. Hepatocytes are treated with or without Ezetimibe (10 μM, 1 h) and incubated with palmitic acid (PA, 0.5 mM, 24 h)[2].
Synonyms SCH 58235
Molecular Weight 409.43
Formula C24H21F2NO3
CAS No. 163222-33-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 75 mg/mL (183.2 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: 75 mg/mL (183.2 mM)

TargetMolReferences and Literature

1. Clader JW, et al. J Med Chem, 2004, 47(1), 1-9. 2. During A, et al. J Nutr, 2005, 135(10), 2305-2312. 3. Davis HR Jr, et al. Arterioscler Thromb Vasc Biol, 2001, 21(12), 2032-2038. 4. Delaney WE 4th, et al. Antimicrob Agents Chemother, 2006, 50(7), 2471-2477. 5. van Heek M, et al. Br J Pharmacol, 2001, 134(2), 409-417. 6. Chang E, et al. Ezetimibe improves hepatic steatosis in relation to autophagy in obese and diabetic rats. World J Gastroenterol. 2015 Jul 7;21(25):7754-63. 7. Lee DH, et al. Ezetimibe, an NPC1L1 inhibitor, is a potent Nrf2 activator that protects mice from diet-induced nonalcoholic steatohepatitis. Free Radic Biol Med. 2016 Sep 12;99:520-532.

TargetMolCitations

1. Chen F, Shi Q, Pei F, et al. A systems‐level study reveals host‐targeted repurposable drugs against SARS‐CoV‐2 infection. Molecular Systems Biology. 2021, 17(8): e10239

Related compound libraries

This product is contained In the following compound libraries:
Anti-Neurodegenerative Disease Compound Library Anti-Cancer Drug Library Anti-Cancer Approved Drug Library Anti-Cancer Clinical Compound Library Transcription Factor-Targeted Compound Library Anti-Aging Compound Library Anti-Cancer Compound Library NF-κB Signaling Compound Library FDA-Approved & Pharmacopeia Drug Library Ferroptosis Compound Library

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Keywords

Ezetimibe 163222-33-1 Autophagy Immunology/Inflammation Membrane transporter/Ion channel Others NPC1L1 Nrf2 SCH58235 inhibit Keap1-Nrf2 Inhibitor SCH 58235 SCH-58235 inhibitor

 

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