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Fluvastatin sodium

Catalog No. T1487 CAS 93957-55-2

Synonyms: XU 62320 sodium, XU-62-320, Fluvastatin sodium salt

Fluvastatin sodium (Fluvastatin sodium salt), a competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase (HMGCR), is a commonly used cholesterol lowering agent.

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Fluvastatin sodium, CAS 93957-55-2

Pack Size	Availability	Price/USD
10 mg	In stock	$ 30.00
25 mg	In stock	$ 44.00
50 mg	In stock	$ 63.00
100 mg	In stock	$ 88.00
200 mg	In stock	$ 123.00
500 mg	In stock	$ 198.00
1 mL * 10 mM (in DMSO)	In stock	$ 63.00

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Purity: 99.46%

Purity: 98.54%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Fluvastatin sodium (Fluvastatin sodium salt), a competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase (HMGCR), is a commonly used cholesterol lowering agent.
Targets&IC50	HMG-CoA reductase:8 nM
In vitro	In a rabbit model, daily administration of Fluvastatin (10 mg/kg) significantly reversed the inhibition of acetylcholine-induced vasodilation, effectively reducing hyperlipidemia.
In vivo	In human aortic smooth muscle cells, Fluvastatin (100 nM) reduces the formation of superoxide anion radicals activated by angiotensin II. In CHL/IU cells, Fluvastatin (8 μM) offers protection against DNA damage. It significantly inhibits the formation of thiobarbituric acid-reactive substances in lipid peroxidation initiated by divalent iron ions (IC50=12 μM). Fluvastatin (1-100 μM) can inhibit lipid peroxidation mediated by peroxyl radicals induced by 2,2'-azobis(2-amidinopropane) dihydrochloride and 2,2'-azobis.

Synonyms	XU 62320 sodium, XU-62-320, Fluvastatin sodium salt
Molecular Weight	433.45
Formula	C24H25FNNaO4
CAS No.	93957-55-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 10.8 mg/mL (25 mM)

DMSO: 43.3 mg/mL (100 mM)

References and Literature

1. Dansette PM, et al. Exp Toxicol Pathol, 2000, 52(2), 145-148. 2. Yamamoto A, et al. J Pharm Pharmacol, 2001, 53(2), 227-232. 3. Imaeda A, et al. Free Radic Res, 2001, 35(6), 789-801. 4. Kugi M, et al. Cardiovasc Drugs Ther, 2002, 16(3), 203-207. 5. Mitani H, et al. Br J Pharmacol, 1996, 119(6), 1269-1275.

Citations

1. Zhang W, Pan X, Xu Y, et al.Mevalonate improves anti-PD-1/PD-L1 efficacy by stabilizing CD274 mRNA.Acta Pharmaceutica Sinica B.2023

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Anti-Cancer Approved Drug Library Inhibitor Library Drug Repurposing Compound Library Bioactive Lipid Compound Library Fluorochemical Library FDA-Approved Drug Library Apoptosis Compound Library Oxidation-Reduction Compound Library

Related Products

Related compounds with same targets

FA16 NADPH tetrasodium salt ML385 FINO2 D-glutamine Gallic acid Ciclopirox Dopamine hydrochloride

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Fluvastatin sodium 93957-55-2 Apoptosis Autophagy Metabolism Ferroptosis HMG-CoA Reductase Inhibitor HMG-CoA Reductase (HMGCR) Nrf2-dependent muscle pathway XU 62320 sodium HMG-CoA smooth inhibit antioxidant XU 62-320 stress reductase Fluvastatin vascular oxidative XU-62-320 Fluvastatin sodium salt inhibitor

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