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Foscarnet sodium

Catalog No. T0220 CAS 63585-09-1

Synonyms: Phosphonoformate

Foscarnet sodium (Phosphonoformate) is an antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpesviruses and HIV.

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Foscarnet sodium, CAS 63585-09-1

Pack Size	Availability	Price/USD
50 mg	In stock	$ 41.00
100 mg	In stock	$ 66.00
1 mL * 10 mM (in DMSO)	In stock	$ 55.00

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Purity: 98.52%

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Description	Foscarnet sodium (Phosphonoformate) is an antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpesviruses and HIV.
In vitro	Foscarnet Sodium is able to penetrate into cells and inhibit viral replication by inhibiting viral DNA synthesis. Foscarnet Sodium (300 μM) displays a more than 95% inhibition on HTLV-III reverse transcriptase activity in H9 cells infected with HTLV-III. [1] Foscarnet Sodium has a low cellular toxicity, but shows an inhibition of cell proliferation at high concentrations, which is reversed after drug removal. Incubation 0.5-1 mM Foscarnet Sodium with HeLa cells or primary human lung fibroblast for 24-48 hr inhibited 50% DNA synthesis and/or cell proliferation. [1] Foscarnet Sodium is able to bind with the heparin-binding domain of FGF2 and inhibits FGF2 induced cell proliferation. Foscarnet Sodium (25 μM) treating HUVEC cells for 48 hr reduced FGF2-induced cellular proliferation by 20%. Foscarnet Sodium (0.5-1 mM) reduced the 24h proliferation rate of CAL-62 cell, a Human thyroid anaplastic carcinoma cell line which expresses FGF2, to nearly 80%. [2]
In vivo	Foscarnet Sodium display an efficient therapy effect on animal with virus diseases, such as cutaneous infection, herpes keratitis, genital infection, or systemic and interacerebral infection. For example, Foscarnet Sodium (100 mM) applied at initiated 48 h post inoculation with twice daily applications of 30 μL for 4 days, displays a more than 70% reduction in cumulative score after inoculation with HSV-1 strain C42. Foscarnet Sodium (20 mg/kg) given as an aerosol to mice infected with murine CMV caused a reduction of 60% in lung titers. [1]
Kinase Assay	Reverse transcriptase assays: Reverse transcriptase assays are carried out in a reaction mixture (50 μL) containing 50 mM Tris-HCl (pH 7.5), 5 mM DTT, 100 mM potassium chloride, 0.01% Triton X-100 or NP40, 10 μg/ml (dT)15.(A)n as template primer and [3H] deoxythymidine triphospahate. The reaction mixture is incubated for 1 hr at 37 ℃ and stopped by the addition of 50 μg of yeast tRNA and 2 mL of 10% solution of trichloroacetic acid containing 1 mM sodium pyrophosphate. The samples are filtered on filters (0.45 μm), washed first with 5% TCA solution for 5 times and then with 2 ml of 70% ethanol. The filters are dried, scintillation fluid is added and the radioactivity counted in a counter.
Cell Research	CAL-62 cells are placed on 96 well plates at 8×103 cells/well in 100 μL DMEM for 24 h. Then medium is replaced by fresh DMEM with or without foscarnet. After 48 h of incubation, 20 μL of CellTiter 96AQ solution is added to the cells and incubated for 2-4 h. The quantity of formazan product as measured by the absorbance at 492 nm.(Only for Reference)

Synonyms	Phosphonoformate
Molecular Weight	191.95
Formula	CNa3O5P
CAS No.	63585-09-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 3 mg/mL (15.63 mM)

DMSO: 7 mg/mL (36.47 mM)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

References and Literature

1. Oberg B. Pharmacol Ther, 1989, 40(2), 213-285. 2. Rose K. Biomed Pharmacother, 2013, 67(1), 53-57. 3. Sarin PS, et al. Biochem Pharmacol, 1985, 34(22), 4075-4079. 4. Alenius S, et al. Antimicrob Agents Chemother, 1978, 14(3), 408-413.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Anti-Cancer Approved Drug Library Inhibitor Library Anti-Cancer Drug Library Preclinical Compound Library Anti-Infection Compound Library Anti-COVID-19 Compound Library Anti-Metabolism Disease Compound Library Approved Drug Library FDA-Approved & Pharmacopeia Drug Library

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Keywords

Foscarnet sodium 63585-09-1 Cell Cycle/Checkpoint DNA Damage/DNA Repair Microbiology/Virology Virus Protease Reverse Transcriptase DNA/RNA Synthesis Phosphonoformate Phosphonoformic acid trisodium replication Inhibitor inhibit retinitis Trisodium phosphonoformate Foscarnet suppression cytomegalovirus reversible antiherpesvirus DNA viral polymerase inhibitor

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