Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GSK621 is a specific and potent AMPK activator.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 50.00 | |
5 mg | In stock | $ 109.00 | |
10 mg | In stock | $ 189.00 | |
25 mg | In stock | $ 372.00 | |
50 mg | In stock | $ 549.00 | |
100 mg | In stock | $ 783.00 |
Description | GSK621 is a specific and potent AMPK activator. |
In vitro | In AML cell lines and primary AML samples, GSK621 markedly increases phosphorylation at AMPKα T172, a marker of AMPK activation. In a set of 20 cell lines, GSK621 reduces the proliferation of all 20 lines with IC50 ranged from 13-30 μM, and increases apoptosis in 17 (85%) lines. In addition, GSK621 also triggers autophagy, which partially contributes to AML cell death. [1] |
In vivo | In nude mice bearing MOLM-14 xenografts, GSK621 (30 mg/kg, i.p.) reduces leukemia growth and significantly extends survival by enhancing AMPK activity and the induction of apoptosis. [1] |
Kinase Assay | AMPK enzymatic assay: HEPG2 cells are treated with increasing doses of A-769662 or GSK621, and ACC S79 phosphorylation is assessed as a surrogate marker for AMPK activation using a commercially available ELISA kit. |
Cell Research | Twenty AML cell lines are treated with log10 dilutions of GSK621 and relative viability is determined by CellTiter-Glo?assay. IC50 of GSK621 among these 20 cell lines is calculated using the Prism software and are presented as log[C] with [C] in mol/l (M). Results are presented for 5 different cell lines per panel.(Only for Reference) |
Molecular Weight | 489.91 |
Formula | C26H20ClN3O5 |
CAS No. | 1346607-05-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 90 mg/mL (183.7 mM)
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
H2O: < 1 mg/mL (insoluble or slightly soluble)
You can also refer to dose conversion for different animals. More
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GSK621 1346607-05-3 Apoptosis Autophagy Chromatin/Epigenetic PI3K/Akt/mTOR signaling AMPK CHOP inhibit AMP-activated protein kinase Inhibitor GSK-621 UPR PERK ATF4 GSK 621 ER Stress inhibitor