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GW806742X

Catalog No. T11520   CAS 579515-63-2

GW806742X is an inhibitor of Mixed Lineage Kinase Domain-Like protein (MLKL) which binds the MLKL pseudokinase domain (Kd: 9.3 μM) with anti-necroptosis activity. GW806742X has activity against VEGFR2.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
GW806742X Chemical Structure
GW806742X, CAS 579515-63-2
Pack Size Availability Price/USD Quantity
2 mg In stock $ 30.00
5 mg In stock $ 47.00
10 mg In stock $ 64.00
25 mg In stock $ 122.00
50 mg In stock $ 198.00
100 mg In stock $ 367.00
1 mL * 10 mM (in DMSO) In stock $ 60.00
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Purity: 99.07%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description GW806742X is an inhibitor of Mixed Lineage Kinase Domain-Like protein (MLKL) which binds the MLKL pseudokinase domain (Kd: 9.3 μM) with anti-necroptosis activity. GW806742X has activity against VEGFR2.
Targets&IC50 MLKL:(kd)9.3 μM
In vitro GW806742X (1 μM) retards MLKL translocation to the membrane.GW806742X (0.1-10000 nM) rescues 50% of wild-type mouse dermal fibroblasts (MDFs) from TSQ-induced necroptosis with an IC50< 50 nM when 1 ng/mL TNF is used.
Molecular Weight 573.55
Formula C25H22F3N7O4S
CAS No. 579515-63-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 125 mg/mL (217.94 mM)

TargetMolReferences and Literature

1. Hildebrand JM, et al. Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death. Proc Natl Acad Sci U S A. 2014 Oct 21;111(42):15072-7. 2. Yan B, et al. Discovery of a new class of highly potent necroptosis inhibitors targeting the mixed lineagekinase domain-like protein. Chem Commun (Camb). 2017 Mar 28;53(26):3637-3640.

Related compound libraries

This product is contained In the following compound libraries:
Tyrosine Kinase Inhibitor Library Anti-Prostate Cancer Compound Library Anti-Ovarian Cancer Compound Library Anti-Obesity Compound Library Anti-Cancer Compound Library MAPK Inhibitor Library Bioactive Compound Library Covalent Inhibitor Library Anti-Colorectal Cancer Compound Library Angiogenesis related Compound Library

Related Products

Related compounds with same targets
IM-54 AZ7550 trimesylate salt Cerdulatinib hydrochloride LY-364947 (E/Z)-Necrosulfonamide Necrosulfonamide PRT062607 hydrochloride MLKL-IN-2

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Keywords

GW806742X 579515-63-2 Angiogenesis MAPK Tyrosine Kinase/Adaptors VEGFR MLK death translocation GW-806742X Vascular endothelial growth factor receptor membrane Inhibitor TSQ MLKs inhibit HUVEC Mixed Lineage Kinase necroptotic inhibitor

 

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