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Guanabenz Acetate

Catalog No. T6522 CAS 23256-50-0

Synonyms: Wy8678 acetate, BR-750, Wytensin

Guanabenz Acetate (Wytensin) is a specific agonist of adrenergic receptor. The pEC50 for α2a-adrenergic receptor, α2b-adrenergic receptor and α2c-adrenergic receptor is 8.25, 7.01 and ~5, respectively.

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Guanabenz Acetate, CAS 23256-50-0

Pack Size	Availability	Price/USD	Quantity
500 mg	In stock	$ 42.00
1 mL * 10 mM (in DMSO)	In stock	$ 30.00

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Purity: 99.83%

Purity: 99%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Guanabenz Acetate (Wytensin) is a specific agonist of adrenergic receptor. The pEC50 for α2a-adrenergic receptor, α2b-adrenergic receptor and α2c-adrenergic receptor is 8.25, 7.01 and ~5, respectively.
Targets&IC50	α2C-adrenoceptor:<5(pEC50), α2B-adrenoceptor:7.01(pEC50), α2A-adrenoceptor:8.25(pEC50)
In vitro	Guanabenz inhibits the response of vascular contractions in various processes and initiates normal sympathetic nerve discharge, while also antagonizing the stimulation of the sympathetic nervous system. Administering 0.5 mg/kg of Guanabenz intravenously in anesthetized hypertensive rats and dogs leads to a reduction in blood pressure and heart rate. Moreover, an intravenous injection of 0.1 mg/kg Guanabenz in anesthetized dogs initially causes an increase in blood pressure due to the action of the sympathetic nervous system, followed by a decrease in cardiac output, contractility, and heart rate.
In vivo	In mammalian MovS6 cells, 10 μM of Guanabenz facilitates the complete clearance of PrPSc. Additionally, in HEK293 cells transfected with rat inducible nitric oxide synthase (nNOS), 30 μM Guanabenz induces a time-dependent reduction in nNOS activity, with a Ki value of 1 μM. In HEK 293 cells, treatment with 50 μM Guanabenz for 3 hours results in approximately a 75% decrease in the accumulation of nitrites and nitrates within the cells. Furthermore, treatment with 100 μM Guanabenz for 24 hours leads to about a 35% reduction in the quantity of inducible nitric oxide synthase protein detected by immunological methods.

Synonyms	Wy8678 acetate, BR-750, Wytensin
Molecular Weight	291.13
Formula	C8H8Cl2N4·C2H4O2
CAS No.	23256-50-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 21.8 mg/mL (75 mM)

References and Literature

1. Jasper JR, et al. Biochem Pharmacol, 1998, 55(7), 1035-1043. 2. Noguchi S, et al. J Biol Chem, 2000, 275(4), 2376-2380. 3. Tribouillard-Tanvier D, et al. PLoS One, 2008, 3(4), e1981. 4. Baum T, et al. J Pharmacol Exp Ther, 1970, 171(2), 276-287. 5. Baum T, et al. Experientia, 1969, 25(10), 1066-1067.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library Anti-Neurodegenerative Disease Compound Library GPCR Compound Library Anti-Cancer Approved Drug Library Drug Repurposing Compound Library Neurotransmitter Receptor Compound Library Approved Drug Library Anti-Alzheimer's Disease Compound Library Orally Active Compound Library

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Keywords

Guanabenz Acetate 23256-50-0 GPCR/G Protein Neuroscience Adrenergic Receptor Wy 8678 BR750 Guanabenz Beta Receptor Wy8678 Wy8678 acetate BR-750 inhibit Wy8678 Acetate Wytensin BR 750 Inhibitor Wy-8678 inhibitor

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